ArticleJournal of Alzheimer's disease : JAD2018
Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Awareness impairment in Alzheimer's disease and frontotemporal dementia: a systematic MRI review.Journal of neurology · 2023Pooled it
- Neuroimaging studies of acupuncture on Alzheimer's disease: a systematic review.BMC complementary medicine and therapies · 2023Pooled it
- What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.Neurobiology of aging · 2020Pooled it
- Neural correlates of altered insight in frontotemporal dementia: a systematic review.NeuroImage. Clinical · 2019Pooled it
- Trajectories of Self-Awareness Across the Alzheimer's Disease Spectrum: A Systematic Review of Its Potential Contribution to Early Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- Modulating the default mode network with deep TMS: a proof-of-concept framework with potential relevance to circuits implicated in lack of awareness of cognitive decline.Frontiers in aging neuroscience · 2026Article
- Prediction Model and Nomogram for Amyloid Positivity Using Clinical and MRI Features in Individuals With Subjective Cognitive Decline.Human brain mapping · 2025Article
- When visual metacognition fails: widespread anosognosia for visual deficits.Trends in cognitive sciences · 2024Review
- Cognition in Patients with Spinocerebellar Ataxia 1 (SCA1) and 2 (SCA2): A Neurophysiological and Neuropsychological Approach.Journal of clinical medicine · 2024Article
- Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain.Communications medicine · 2024Article
- Self-supervised multimodal learning for group inferences from MRI data: Discovering disorder-relevant brain regions and multimodal links.NeuroImage · 2024Article
- Electrophysiological and neuropsychological assessment of cognition in spinocerebellar ataxia type 1 patients: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Impaired self-awareness of cognitive deficits in Parkinson's disease relates to cingulate cortex dysfunction.Psychological medicine · 2023Article
- Metacognition, cortical thickness, and tauopathy in aging.Neurobiology of aging · 2022Article
- Anosognosia in Dementia: Evaluation of Perfusion Correlates Using 99mTc-HMPAO SPECT and Automated Brodmann Areas Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Altered metamemory precedes cognitive impairment in subjective cognitive decline with positive amyloid-beta.Frontiers in aging neuroscience · 2022Article
- Alzheimer's Disease and Empathic Abilities: The Proposed Role of the Cingulate Cortex.Journal of Alzheimer's disease reports · 2021Review
- Effects of Anosognosia on Static and Dynamic Amplitudes of Low-Frequency Fluctuation in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Altered Interplay Among Large-Scale Brain Functional Networks Modulates Multi-Domain Anosognosia in Early Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Subjective cognitive decline: opposite links to neurodegeneration across the Alzheimer's continuum.Brain communications · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnosognosia is a frequent symptom of Alzheimer's disease (AD), but its neural substrates remain in question.
objectiveIn this study, we combined neuroimaging with a neuropsychological evaluation to assess neural substrates of anosognosia.
methodsWe prospectively recruited 30 patients with probable early-stage AD and matched healthy controls. Participants underwent MRI, FDG-PET, and a neuropsychological evaluation that includes an assessment of anosognosia. In the AD group, correlations between the anosognosia score, neuroimaging modalities, and neuropsychological performance were performed.
resultsAtrophy and hypometabolism were correlated with the anosognosia score in the left dorsal anterior cingulate cortex. The anosognosia score was also correlated with atrophy of the cerebellar vermis, the left postcentral gyrus, and the right fusiform gyrus. No relation was found between anosognosia and the neuropsychological assessment. DISCUSSION: Structural and metabolic alteration in the dorsal anterior cingulate cortex seems to be associated with a diminution of awareness in patients with early-stage AD.
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