ArticleBMJ open2018
Metagenomic analysis of gut microbial communities from a Central Asian population.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
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- Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.Microorganisms · 2022Review
- Study of gut microbiota alterations in Alzheimer's dementia patients from Kazakhstan.Scientific reports · 2022Article
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- Public human microbiome data are dominated by highly developed countries.PLoS biology · 2022Article
- Butyrate Production Pathway Abundances Are Similar in Human and Nonhuman Primate Gut Microbiomes.Molecular biology and evolution · 2022Article
- mBodyMap: a curated database for microbes across human body and their associations with health and diseases.Nucleic acids research · 2022Article
- Dispersal strategies shape persistence and evolution of human gut bacteria.Cell host & microbe · 2021Article
- Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.Nature communications · 2021Article
- Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.Genome biology · 2021Article
- Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle.Scientific reports · 2021Article
- Cross-Sectional Study on the Gut Microbiome of Parkinson's Disease Patients in Central China.Frontiers in microbiology · 2021Article
- Dynamic Changes in Microbiome Composition Following Mare's Milk Intake for Prevention of Collateral Antibiotic Effect.Frontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChanges in the gut microbiota are increasingly recognised to be involved in many diseases. This ecosystem is known to be shaped by many factors, including climate, geography, host nutrition, lifestyle and medication. Thus, knowledge of varying populations with different habits is important for a better understanding of the microbiome.
designWe therefore conducted a metagenomic analysis of intestinal microbiota from Kazakh donors, recruiting 84 subjects, including male and female healthy subjects and metabolic syndrome (MetS) patients aged 25-75 years, from the Kazakh administrative centre, Astana. We characterise and describe these microbiomes, the first deep-sequencing cohort from Central Asia, in comparison with a global dataset (832 individuals from five countries on three continents), and explore correlations between microbiota, clinical and laboratory parameters as well as with nutritional data from Food Frequency Questionnaires.
resultsWe observe that Kazakh microbiomes are relatively different from both European and East Asian counterparts, though similar to other Central Asian microbiomes, with the most striking difference being significantly more samples falling within the
conclusionTaken together, this exploratory study describes gut microbiome data from an understudied population, providing a starting point for further comparative work on biogeography and research on widespread diseases. TRIAL REGISTRATION NUMBER: ISRCTN37346212; Post-results.
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