Evidence map›Paper›PMID 30056384›Full record

Trial reportBMJ open2018

Feasibility of data linkage in the PARAMEDIC trial: a cluster randomised trial of mechanical chest compression in out-of-hospital cardiac arrest.

Chen Ji, Tom Quinn, Lucia Gavalova, Ranjit Lall, Charlotte Scomparin, Jessica Horton, Charles D Deakin, Helen Pocock, Michael A Smyth, Nigel Rees and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03699137 (Use and Impact of the Pre-hospital 12-lead Electrocardiogram in the Primary PCI Era), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03699137 completednot on this mapstarted 2019, after this paper: background citation

Use and Impact of the Pre-hospital 12-lead Electrocardiogram in the Primary PCI Era: Mixed Methods Study (PHECG2)

TypeobservationalSponsorKingston UniversityRan2019 to 2020Enrolled420,048ConditionsAcute Coronary Syndrome, STEMI, Non STEMIArmsNo interventions
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Database quality assessment in research in paramedicine: a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chen JiWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Tom QuinnFaculty of Health, Social Care & Education, Kingston University and St George's, University of London, London, UK.
Lucia GavalovaFaculty of Health, Social Care & Education, Kingston University and St George's, University of London, London, UK.
Ranjit LallWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Charlotte ScomparinWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Jessica HortonWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Charles D DeakinNIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Helen PocockSouth Central Ambulance Service NHS Foundation Trust, Otterbourne, UK.
Michael A SmythWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.ORCID 0000-0003-0220-2223
Nigel ReesWelsh Ambulance Service NHS Trust, Cardiff, UK.
Samantha J Brace-McDonnellWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Simon GatesWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Gavin D PerkinsWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.

Funding

Department of Health 07/37/69
6 · The paper itself

Abstract

objectivesThere is considerable interest in reducing the cost of clinical trials. Linkage of trial data to administrative datasets and disease-specific registries may improve trial efficiency, but it has not been reported in resuscitation trials conducted in the UK. To assess the feasibility of using national administrative and clinical datasets to follow up patients transported to hospital following attempted resuscitation in a cluster randomised trial of a mechanical chest compression device in out-of-hospital cardiac arrest.

methodsHospital data on trial participants were requested from Hospital Episode Statistics (HES), the Intensive Care National Audit and Research Centre, and Myocardial Ischaemia National Audit Project and National Audit of Percutaneous Coronary Interventions, using unique patient identifiers. Linked data were received between June 2014 and June 2015.

resultsOf 4471 patients randomised in the pre-hospital randomised assessment of a mechanical compression device in cardiac arrest (PARAMEDIC) trial, 2398 (53.6%) were not known to be deceased at emergency department arrival and were eligible for linkage. We achieved an overall match rate of 86.7% in the combined HES accident and emergency, inpatient and critical care dataset, with variable match rates (4.2%-80.4%) in individual datasets. Patient demographics, cardiac arrest-related characteristics and major outcomes were predominantly similar between HES matched and unmatched groups, in the linkage apart from location, response time and return of spontaneous circulation (ROSC) at handover.

conclusionsThis study shows that it is feasible to track patients from the prehospital setting through to hospital admission using routinely available administrative datasets with a moderate to high degree of success. This approach has the potential to complement the trial data with the demographic and clinical management information about the studied cohort, as well as to improve the efficiency and reduce the costs of follow-up in cardiac arrest trials. CLINICAL

trial registrationISRCTN08233942; Post-results.

Indexed as

Emergency Medical ServicesHeart MassageCardiopulmonary ResuscitationCluster AnalysisEmergency Medical TechniciansFeasibility StudiesHumansInformation Storage and RetrievalOut-of-Hospital Cardiac ArrestRegistriesadult cardiologycardiac arrestclinical trialsdata linkage

Identifiers

PMID30056384
PMCPMC6067361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.