Evidence map›Paper›PMID 30056178›Full record

ArticleNeurotoxicology2018

Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig.

Christina M Wilhelm, Thomas H Snider, Michael C Babin, Gennady E Platoff, David A Jett, David T Yeung

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Christina M WilhelmBattelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693, USA. Electronic address: wilhelmc@battelle.org.
Thomas H SniderBattelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693, USA.
Michael C BabinBattelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693, USA. Electronic address: babinm@battelle.org.
Gennady E PlatoffNational Institutes of Health/National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address: platoffg@niaid.nih.gov.
David A JettNational Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. Electronic address: jettd@ninds.nih.gov.
David T YeungNational Institutes of Health/National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address: dy70v@nih.gov.
Battelle · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · US

Funding

Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Organophosphorus (OP) compounds, including pesticides and chemical warfare nerve agents (CWNA), are threats to the general population as possible weapons of terrorism or by accidental exposure whether through inadvertent release from manufacturing facilities or during transport. To mitigate the toxicities posed by these threats, a therapeutic regimen that is quick-acting and efficacious against a broad spectrum of OPs is highly desired. The work described herein sought to assess the protective ratio (PR), median effective doses (ED

Indexed as

AnimalsChemical Warfare AgentsCholinesterase InhibitorsCholinesterase ReactivatorsGuinea PigsInsecticidesMaleOrganophosphatesOrganothiophosphorus CompoundsOximesPhoratePralidoxime CompoundsPyridinium CompoundsSarinChemical Warfare AgentsCholinesterase InhibitorsCholinesterase ReactivatorsHLo 7InsecticidesOrganophosphatesOrganothiophosphorus CompoundsOximesPhoratepralidoximePralidoxime CompoundsPyridinium CompoundsSarinVX-agentED(50)HEDHLö-7 DMSMMB4 DMSPhorate-oxonProtective ratio

Identifiers

PMID30056178
PMCPMC6153028
OpenAlexW2884137033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.