Evidence map›Paper›PMID 30056068›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2018

Liquid biopsies for hepatocellular carcinoma.

Ying-Hsiu Su, Amy K Kim, Surbhi Jain

Abstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Genetic screening of liver cancer: State of the art.World journal of hepatology · 2024
    Review
  4. Article
  5. Article
  6. Detection ofDiagnostics (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Circulating tumor cells in the clinical cancer diagnosis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying-Hsiu SuThe Baruch S. Blumberg Institute, Doylestown, Pennsylvania. Electronic address: Ying-hsiu.Su@bblumberg.org.
Amy K KimDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins School of Medicine, Baltimore Maryland. Electronic address: akim97@jhmi.edu.
Surbhi JainJBS Science, Inc., Doylestown, Pennsylvania. Electronic address: sjain@jbs-science.com.

Funding

Development of a Urine Test for the Early Detection of Liver CancerR44CA165312 · NCI · JBS SCIENCE, INC. · PI LIN, SELENA · 2013 to 2020
$4.9M
Development of cell-free DNA assays for HCC screening and liquid biopsyR01CA202769 · NCI · BARUCH S. BLUMBERG INSTITUTE · PI SU, YING-HSIU · 2016 to 2020
$2.1M
Urine DNA Kit for monitoring HCC recurrenceR43CA213610 · NCI · JBS SCIENCE, INC. · PI JAIN, SURBHI · 2016 to 2016
$300k
NCI NIH HHS R01 CA202769NCI NIH HHS R43 CA213610NCI NIH HHS R44 CA165312
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the world's second leading cause of cancer death; 82.4% of patients die within 5 years. This grim prognosis is the consequence of a lack of effective early detection tools, limited treatment options, and the high frequency of HCC recurrence. Advances in the field of liquid biopsy hold great promise in improving early detection of HCC, advancing patient prognosis, and ultimately increasing the survival rate. In an effort to address the current challenges of HCC screening and management, several studies have identified and evaluated liver-cancer-associated molecular signatures such as genetic alterations, methylation, and noncoding RNA expression in the form of circulating biomarkers in body fluids and circulating tumor cells of HCC patients. In this review, we summarize the recent progress in HCC liquid biopsy, organized by the intended clinical application of the reported study.

Indexed as

Carcinoma, HepatocellularCell-Free Nucleic AcidsDNA MethylationEarly Detection of CancerHumansLiquid BiopsyLiver NeoplasmsMutationNeoplastic Cells, CirculatingCell-Free Nucleic Acids

Identifiers

PMID30056068
PMCPMC6483086

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.