ArticleCancer epidemiology2018
Which indicators of early cancer diagnosis from population-based data sources are associated with short-term mortality and survival?
Article in Cancer epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 16 citations in OpenAlex.
- Assessing the impact of timely diagnosis on psychological outcomes and quality of life for cancer patients: A scoping review.PloS one · 2026Article
- Prehospital care for ovarian cancer in Catalonia: could we do better in primary care? Retrospective cohort study.BMJ open · 2022Article
- A scoping review on population-centered indicators for cancer care continuum.Frontiers in public health · 2022Article
- Development and validation of a nomogram prediction model for early mortality in patients with primary malignant cardiac tumors.Annals of translational medicine · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
backgroundA key component of recent English cancer policy is the monitoring of trends in early diagnosis of cancer. Early diagnosis can be defined by the disease stage at diagnosis or by other indicators derived from electronic health records. We evaluate the association between different early diagnosis indicators and survival, and discuss the implementation of the indicators in surveillance of early diagnosis.
methodsWe searched the PubMed database and grey literature to identify early diagnosis indicators and evaluate their association with survival. We analysed cancer registrations for 355,502 cancer patients diagnosed in England during the period 2009-2013, and quantified the association between each early diagnosis indicator and 30-day mortality and five-year net survival.
resultsEach incremental difference in stage (I-IV) predicts lower 5-year survival, so prognostic information is lost in comparisons which use binary stage indicators. Patients without a recorded stage have high risk of death shortly following diagnosis and lower 5-year survival. Emergency presentation is independently associated with lower five-year survival. Shorter intervals between first symptoms and diagnosis are not consistently associated with improved survival, potentially due to confounding from tumour characteristics.
interpretationContrary to current practice, we recommend that all the stage information should be used in surveillance. Patients missing stage should also be included to minimise bias. Combined data on stage and emergency presentation could be used to create summary prognostic measures. More work is needed to create statistics based on the diagnostic interval that will be useful for surveillance.
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