SynthesisBMC complementary and alternative medicine2018
Yinzhihuang oral liquid combined with phototherapy for neonatal jaundice: a systematic review and meta-analysis of randomized clinical trials.
Synthesis in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Yinzhihuang injection as adjuvant treatment for neonatal hyperbilirubinemia: a systematic review and meta-analysis of randomized clinical trials.Frontiers in pharmacology · 2024Pooled it
- Age-specific ETCOc measured by non-dispersive infrared spectroscopy predicts neonatal phototherapy.Pediatric research · 2026Article
- Advances in laboratory diagnosis of neonatal hyperbilirubinemia and peculiarities in plateau regions: a review of evidence.Frontiers in pediatrics · 2026Review
- Synergistic effects of ferulic acid and wogonin on cholestatic liver injury via gut microbiota modulation.NPJ biofilms and microbiomes · 2025Article
- The Effect of Intravenous Albumin Administration Before Exchange Transfusion in Infants With Hyperbilirubinemia: A Meta-Analysis.Health science reports · 2025Review
- Yinzhihuang Oral Liquid Alleviates Intrahepatic Cholestasis of Pregnancy: Integrated Bioinformatics and Experimental Mechanistic Insight.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- "Light" on Phototherapy-Complications and Strategies for Shortening Its Duration, A Review of the Literature.Children (Basel, Switzerland) · 2023Review
- Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Yinzhihuang Oral Liquid in Treating Neonatal Hyperbilirubinemia.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Exploration of the pathogenic factors of neonatal jaundice and the clinical effect of blue phototherapy.American journal of translational research · 2021Article
- Effect of humanized care in the treatment of neonatal jaundice and its effect on oxygen saturation.American journal of translational research · 2021Article
- Xiao'er Xiaoji Zhike Oral Liquid Combined with Azithromycin forEvidence-based complementary and alternative medicine : eCAM · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundNeonatal jaundice affects at least 481,000 newborns every year. Phototherapy is recommended but it's effects are limited and adverse reactions can occur. In China, phototherapy combined with Yinzhihuang oral liquid is also used for this condition. This systematic review evaluated the effectiveness and safety of combination therapy with Yinzhihuang oral liquid and phototherapy compared to phototherapy alone for treating neonatal jaundice.
methodA comprehensive literature search was performed in four Chinese databases, two English language databases and two trial registries from inception to June 2017. Two authors independently screened the citations and retrieved full publications for randomized trials on Yinzhihuang oral liquid combined with phototherapy for neonatal jaundice. The methodological quality of the trials was assessed according to the Cochrane Collaboration's tool for assessing risk of bias. Data were analyzed using RevMan 5.3.
resultTotally 17 trials (involving 2561 neonates) were included in this review. Fourteen of them had a high risk of bias. Significant differences were detected between combination therapy and phototherapy alone for serum bilirubin level (MD - 50.25 μmol/L, 95% CI -64.01 to - 36.50, I
conclusionBased on trials with low methodological quality, Yinzhihuang oral liquid combined with phototherapy seemed to be safe and superior to phototherapy alone for reducing serum bilirubin in neonatal jaundice. These potential benefits need to be confirmed in future trials using rigorous methodology.
trial registrationSystematic review registration: [PROSPERO registration: CRD42016037691 ].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.