SynthesisBMC musculoskeletal disorders2018
Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- The effect of Proprioceptive Neuromuscular Facilitation (PNF) therapy on functional recovery in patients with knee joint injury: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Influence of taping on joint proprioception: a systematic review with between and within group meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- The effects of exercise training on knee repositioning sense in people with knee osteoarthritis: a systematic review and meta-analysis of clinical trials.BMC musculoskeletal disorders · 2023Pooled it
- Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients' Motor Function.Computational and mathematical methods in medicine · 2022Trial
- Application of Deep Learning-Based Markerless Pose Estimation in a 3D Exergame System for Knee Osteoarthritis Exercise Management: Development and Preliminary Evaluation.Sensors (Basel, Switzerland) · 2026Article
- Alignment and/or ligament balancing? Towards truly personalized total knee arthroplasty-A narrative review.Journal of experimental orthopaedics · 2026Review
- The effects of ultrasound-guided genicular nerve block on proprioception and static balance in knee osteoarthritis patients.Turkish journal of physical medicine and rehabilitation · 2026Article
- Determining optimal diet/exercise treatment assignment for patients with symptomatic knee osteoarthritis using baseline gait forces.Osteoarthritis and cartilage open · 2025Article
- Predictors of flexion contracture progression following total knee arthroplasty: role of global sagittal alignment and patient age.European journal of medical research · 2025Article
- Lateral meniscus extrusion on preoperative MRI and its impact upon mid-term clinical outcomes following mobile-bearing unicompartmental knee arthroplasty.Journal of orthopaedics · 2025Article
- Increased ankle pushoff alters frontal-plane hip and knee mechanics.Journal of biomechanics · 2025Article
- Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.Journal of orthopaedic surgery and research · 2025Review
- Observation of the Effects of Infrapatellar Fat Pad Excision on the Inflammatory Progression of Knee Osteoarthritis in Mice.Journal of inflammation research · 2025Article
- Article
- Foot and knee deformities in relation to functional limitations and incident osteoarthritis: A prospective cohort study.Osteoporosis and sarcopenia · 2024Article
- Effect of strength training on knee proprioception in patients with knee osteoarthritis: A systematic review and meta-analysis.Sports medicine and health science · 2024Review
- Influence of patients' preoperative expectations on postoperative outcomes after total knee or hip arthroplasty: a systematic review.EFORT open reviews · 2024Article
- A synoptic literature review of animal models for investigating the biomechanics of knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2024Review
- Effect of autogenous osteochondral mosaicplasty on the balance control of patients with cartilage defects of the knee: a pilot study.Journal of orthopaedic surgery and research · 2023Article
- Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundTo investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association.
methodsMEDLINE, EMBASE, CINAHL and SPORTDiscus were searched up until April 2017. Studies were included if they fulfilled the following criteria: the study 1) assessed the association of a biomechanical factor with knee osteoarthritis, or knee osteoarthritis development; 2) reported on skeletal malalignment, muscular dysfunction, impaired proprioception, laxity and abnormal loading during gait; 3) was a cohort study with participants developing knee osteoarthritis and participants not developing knee osteoarthritis, or a case-control or cross-sectional study with participants with knee osteoarthritis and without knee osteoarthritis. Risk of bias was assessed with the QUIPS tool and meta-analyses were performed using random effects models.
resultsOf 6413 unique studies identified, 59 cross-sectional studies were eligible for meta-analyses (9825 participants, 5328 with knee osteoarthritis). No cohort studies fulfilled the inclusion criteria. Compared with healthy controls, patients with knee osteoarthritis have higher odds of having lower muscle strength, proprioception deficits, more medial varus-valgus laxity and less lateral varus-valgus laxity. Patients with medial knee osteoarthritis have higher odds of having a higher knee adduction moment than healthy controls. Level of evidence was graded as 'very low' to 'moderate' quality. Due to large between study differences moderation of other risk factors on biomechanical risk factors could not be evaluated.
conclusionsPatients with knee osteoarthritis are more likely to display a number of biomechanical characteristics. The causal relationship between specific biomechanical factors and the development of knee osteoarthritis could not be determined as no longitudinal studies were included. There is an urgent need for high quality, longitudinal studies to evaluate the impact of specific biomechanical factors on the development of knee osteoarthritis.
trial registration(PROSPERO ID: CRD42015025092 ).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.