Evidence map›Paper›PMID 30055582›Full record

ArticleBMC cancer2018

Classification of gallbladder cancer by assessment of CD8

Jianzhen Lin, Junyu Long, Xueshuai Wan, Jingci Chen, Yi Bai, Anqiang Wang, Xiaobo Yang, Yan Wu, Simon C Robson, Xinting Sang and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  13. Article
  14. CD73 and PD-L1 as Potential Therapeutic Targets in Gallbladder Cancer.International journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. CD8Journal for immunotherapy of cancer · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jianzhen LinDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.
Junyu LongDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.
Xueshuai WanDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.
Jingci ChenSchool of Medicine, Tsinghua University, Beijing, China.
Yi BaiDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.
Anqiang WangDepartment of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing, China.
Xiaobo YangDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.
Yan WuLiver Center and The Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Simon C RobsonLiver Center and The Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Xinting SangDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. sangxt@pumch.cn.
Haitao ZhaoDepartment of Liver Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Peking Union Medical College Hospital, #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. zhaoht@pumch.cn.ORCID http://orcid.org/0000-0002-3444-8044
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeth Israel Deaconess Medical Center · USPeking University · CNTsinghua University · CN

Funding

International Science and Technology Cooperation Projects 2015DFA30650 and 2016YFE0107100
6 · The paper itself

Abstract

backgroundProgrammed death ligand 1/2 (PD-L1/PD-L2) expression has been established as a prognostic factor for various solid tumors and as a predictive factor for PD-1 blockade therapy, but scant data on its role in gallbladder cancer (GBC). The aims of this study were to assess the expression of PD-L1/PD-L2 and the density of CD8

methodsCD8

resultsThe rate of PD-L1-positive (PD-L1

conclusionAnalysis of the tumor immune microenvironment based on CD8

Indexed as

Gallbladder NeoplasmsAdultAgedAged, 80 and overB7-H1 AntigenCD8-Positive T-LymphocytesFemaleHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedPrognosisProgression-Free SurvivalB7-H1 AntigenCD274 protein, humanCD8+ TILsGallbladder cancerImmune microenvironmentImmunohistochemistryPD-L1

Identifiers

PMID30055582
PMCPMC6064069
OpenAlexW2883150683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.