ArticleEnvironment international2018
Endocrine disruptors and neonatal anthropometry, NICHD Fetal Growth Studies - Singletons.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Birth weight in relation to maternal and neonatal biomarker concentration of perfluorooctane sulfonic acid: a meta-analysis and meta-regression from a systematic review.Journal of exposure science & environmental epidemiology · 2025Pooled it
- Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2024Pooled it
- Systematic review and meta-analysis of birth weight and perfluorohexane sulfonate exposures: examination of sample timing and study confidence.Occupational and environmental medicine · 2024Pooled it
- Systematic review and meta-analysis of birth weight and PFNA exposures.Environmental research · 2023Pooled it
- Early-Life Exposure to Per- and Poly-Fluorinated Alkyl Substances and Growth, Adiposity, and Puberty in Children: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases.Clinical epigenetics · 2020Trial
- Mixtures ofToxics · 2025Article
- Maternal obesity and ancestry distance in influencing birth outcomes.International journal of obesity (2005) · 2025Observational
- Association of placental weight and placental-fetal weight ratio with DNA methylation in placenta.Epigenomics · 2025Article
- Mitigating the environmental effects of healthcare: the role of the endocrinologist.Nature reviews. Endocrinology · 2025Review
- Per- and Polyfluoroalkyl Substances and Outcomes Related to Metabolic Syndrome: A Review of the Literature and Current Recommendations for Clinicians.American journal of lifestyle medicine · 2025Review
- Polybrominated diphenyl ethers and gestational weight gain: a multi-center prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2024Article
- Associations between maternal urinary kisspeptin in late pregnancy and decreased fetal growth: a pregnancy-birth cohort study.Frontiers in endocrinology · 2024Article
- Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy.Molecular and cellular endocrinology · 2023Article
- Methods in Public Health Environmental Justice Research: a Scoping Review from 2018 to 2021.Current environmental health reports · 2023Article
- Associations of Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Uterine Fibroid Changes across Pregnancy: NICHD Fetal Growth Studies - Singletons Cohort.Environmental health perspectives · 2023Article
- Racial and ethnic disparities in preterm birth: a mediation analysis incorporating mixtures of polybrominated diphenyl ethers.Frontiers in reproductive health · 2023Article
- Polybrominated diphenyl ethers in early pregnancy and preterm birth: Findings from the NICHD Fetal Growth Studies.International journal of hygiene and environmental health · 2022Article
- Sex-specific placental gene expression signatures of small for gestational age at birth.Placenta · 2022Article
- Association between gestational PFAS exposure and Children's adiposity in a diverse population.Environmental research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIntrauterine exposure to endocrine disrupting chemicals (EDCs) has been equivocally associated with birth weight, length and head circumference with limited attention to anthropometric endpoints such as umbilical circumference and limb lengths.
objectiveTo explore 76 prenatal maternal plasma EDC concentrations in a healthy obstetric cohort and 7 neonatal anthropometric endpoints by maternal race/ethnicity.
methodsThe study cohort comprised 2106 (564 White, 549 Black, 590 Hispanic, 403 Asian) healthy pregnant women recruited from 12 U.S. clinical sites between 2009 and 2012 who were followed through delivery. Neonates underwent standardized anthropometric assessment (weight, length, head and umbilical circumference, and mid- upper arm and thigh length). Plasma EDC concentrations were quantified using high resolution gas chromatography-high resolution mass spectrometry and liquid chromatography-tandem mass spectrometry. EDCs were log-transformed and rescaled by their deviations (SD) when modeled relative to neonatal endpoints using linear regression adjusting for age, education, pre-pregnancy body mass index (BMI), serum cotinine, serum lipids for lipophilic chemicals, and a race/ethnicity interaction term; p-values had false discovery rate correction (<0.05).
resultsThe cohort comprised women aged 28 (SD = 5) years with normal BMIs (23.6 kg/m
conclusionsAmong healthy pregnant women with low risk antenatal profiles and relatively low EDC concentrations, reductions in umbilical circumference and bone lengths may be a sensitive marker of intrauterine EDC exposure, particularly for PFAS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.