ArticleNeurobiology of aging2018
Modeling white matter tract integrity in aging with diffusional kurtosis imaging.
Abstract read
In one paragraph
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- White matter microstructural damage in early treated phenylketonuric patients.Orphanet journal of rare diseases · 2018Pooled it
- Article
- High-Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan.NMR in biomedicine · 2026Article
- Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging.Magma (New York, N.Y.) · 2026Article
- Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.Biopsychosocial science and medicine · 2026Article
- Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes.Autism research : official journal of the International Society for Autism Research · 2025Review
- Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- Intra-voxel angular dispersion of fibers in corpus callosum decreases with healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Age-related alterations in human cortical microstructure across the lifespan: Insights from high-gradient diffusion MRI.Aging cell · 2024Article
- Application of preoperative advanced diffusion magnetic resonance imaging in evaluating the postoperative recurrence of lower grade gliomas.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Uncovering patterns of white matter degeneration in normal aging: Links between morphometry and microstructure.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Volume electron microscopy in injured rat brain validates white matter microstructure metrics from diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain-wide associations between white matter and age highlight the role of fornix microstructure in brain ageing.Human brain mapping · 2023Article
- Alterations in white matter integrity and network topological properties are associated with a decrease in global motion perception in older adults.Frontiers in aging neuroscience · 2023Article
- Validity of Normative Volumetric Estimates from Open Access Software in Amnestic Mild Cognitive Impairment.The journal of prevention of Alzheimer's disease · 2023Observational
- Within-person changes in the aging white matter microstructure and their modifiers: A meta-analysis and systematic review of longitudinal diffusion tensor imaging studies.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease.Annals of neurology · 2022Article
- Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans.Biology · 2022Review
- Fiber Ball White Matter Modeling Reveals Microstructural Alterations in Healthy Brain Aging.Aging brain · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Andreana BenitezCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA. Electronic address: benitez@musc.edu.
Jens H JensenCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Maria Fatima FalangolaCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Paul J NietertDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Joseph A HelpernCenter for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC, USA; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Funding
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4MQuantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and ADR01AG054159 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Andreana Benitez · 2017 to 2026
$8.9MDiffusion and Functional MRI Monitoring of Therapy Response in Alzheimer’s Disease Mouse ModelR01AG057602 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MARIA F FALANGOLA, JENS H JENSEN · 2023 to 2026
$2.7MAssessing Brain Microstructure in Alzheimer's Disease with Advanced Diffusion MRIRF1AG057602 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FALANGOLA, MARIA F, JENSEN, JENS H · 2018 to 2018
$2.1MWhite Matter Tract Integrity Biomarkers of Neurodegeneration in Aging and MCI Administrative SupplementK23AG044434 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BENITEZ, ANDREANA · 2015 to 2020
$914kSouth Carolina Clinical & Translational Research Institute (SCTR)KL2TR000060 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$807kNCATS NIH HHS KL2 TR000060NCATS NIH HHS UL1 TR000062NIA NIH HHS K23 AG044434NIA NIH HHS R01 AG054159NIA NIH HHS R01 AG057602NIA NIH HHS RF1 AG057602
Abstract
Myelin breakdown and neural fiber loss occur in aging. This study used white matter tract integrity metrics derived from biophysical modeling using Diffusional Kurtosis Imaging to assess loss of myelin (i.e., extraaxonal diffusivity, radial direction, D
Indexed as
AgedAged, 80 and overAgingAxonsBrainDiffusion Tensor ImagingFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedModels, NeurologicalMyelin SheathNeural PathwaysWhite MatterAgingDiffusional kurtosis imagingDiffusion MRIWhite matterWhite matter tract integrity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.