ArticleInternational journal for numerical methods in biomedical engineering2018
Combining data from multiple sources to study mechanisms of aneurysm disease: Tools and techniques.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review.Neurosurgical review · 2022Pooled it
- Modeling Perforator Occlusion After Flow Diversion.International journal for numerical methods in biomedical engineering · 2026Article
- Investigation of Contrast Retention in PCOM Aneurysms as a Possible Marker for Instability and Rupture.International journal for numerical methods in biomedical engineering · 2026Article
- Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences.Stroke (Hoboken, N.J.) · 2025Article
- Haemodynamic characteristics of thin-walled regions in intracranial aneurysms: intraoperative imaging and CFD analysis.Acta neurochirurgica · 2025Article
- Competing pathways of intracranial aneurysm growth: linking regional growth distribution and hemodynamics.Journal of neurosurgery · 2025Article
- Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall.International journal for numerical methods in biomedical engineering · 2025Article
- Distribution of rupture sites and blebs on intracranial aneurysm walls suggests distinct rupture patterns in ACom and MCA aneurysms.International journal for numerical methods in biomedical engineering · 2024Article
- Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions.International journal for numerical methods in biomedical engineering · 2024Article
- Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2024Article
- Article
- Differences Between Ruptured Aneurysms With and Without Blebs: Mechanistic Implications.Cardiovascular engineering and technology · 2023Article
- Identification of Small, Regularly Shaped Cerebral Aneurysms Prone to Rupture.AJNR. American journal of neuroradiology · 2022Article
- Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images.International journal of computer assisted radiology and surgery · 2021Article
- Blebs in intracranial aneurysms: prevalence and general characteristics.Journal of neurointerventional surgery · 2021Article
- Modeling intracranial aneurysm stability and growth: an integrative mechanobiological framework for clinical cases.Biomechanics and modeling in mechanobiology · 2020Article
- Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.Annual review of biomedical engineering · 2020Review
- Calcification in Human Intracranial Aneurysms Is Highly Prevalent and Displays Both Atherosclerotic and Nonatherosclerotic Types.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.AJNR. American journal of neuroradiology · 2019Article
- Multiphoton Imaging of Collagen, Elastin, and Calcification in Intact Soft-Tissue Samples.Current protocols in cytometry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionConnecting local hemodynamics, biomechanics, and tissue properties in cerebral aneurysms is important for understanding the processes of wall degeneration and subsequent aneurysm progression and rupture. This challenging problem requires integration of data from multiple sources.
methodsThis paper describes the tools and techniques developed to integrate data from multiple sources, including clinical information, 3D imaging, intraoperative videos, ex vivo micro-computed tomography (CT), and multiphoton microscopy. Central to this approach is a 3D tissue model constructed from micro-CT images of aneurysm samples resected during neurosurgery. This model is aligned to vascular models constructed from 3D clinical images and is used to map and compare flow, biomechanics, and tissue data.
resultsThe approach is illustrated with data of three human intracranial aneurysms. These case studies demonstrated the ability of this approach to study relationships between different factors affecting the aneurysm wall and produced provocative observations that will be further studied with larger series. For instance, "atherosclerotic" and "hyperplastic" looking parts of the aneurysm corresponded to thicker walls and occurred in regions of recirculating flow and low wall shear stress (WSS); thin regions were associated with inflow jets, flow impingement, and high WSS; blebs had walls of varying structures, including calcified, thin, or hyperplastic walls.
conclusionsThe current approach enables the study of interactions of multiple factors thought to be responsible for the progressive degradation and weakening of the aneurysm wall during its evolution.
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