ArticleArthritis care & research2019
Cost-Effectiveness of Diet and Exercise for Overweight and Obese Patients With Knee Osteoarthritis.
Article in Arthritis care & research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of cost-effectiveness analyses of weight loss interventions for knee osteoarthritis.BMJ open · 2026Pooled it
- Health economic evaluation of weight reduction interventions in individuals suffering from overweight or obesity and a musculoskeletal diagnosis-a systematic review.BMC musculoskeletal disorders · 2024Pooled it
- Consequences on Private Insurance Coverage: The AAOS Clinical Practice Guidelines and Hyaluronic Acid Injections.The Journal of bone and joint surgery. American volume · 2020Guideline
- Cost-Effectiveness of Telehealth-Delivered Exercise and Dietary Weight Loss Programs for Knee Osteoarthritis Within a Twelve-Month Randomized Trial.Arthritis care & research · 2023Trial
- Effects of Self-management Program as Adjunctive to Usual Rehabilitation Exercise on Pain and Functional Outcomes in Knee Osteoarthritis: A Randomized Controlled Trial.Journal of research in health sciences · 2023Trial
- Cost-utility analysis and net monetary benefit of Platelet Rich Plasma (PRP), intra-articular injections in compared to Plasma Rich in Growth Factors (PRGF), Hyaluronic Acid (HA) and ozone in knee osteoarthritis in Iran.BMC musculoskeletal disorders · 2023Trial
- Net cost savings arising from patient completion of an active self-management program.PloS one · 2023Trial
- The movement imperative: reimagining healthcare through the lens of human movement.Frontiers in sports and active living · 2026Review
- The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity.Annals of internal medicine · 2025Article
- The Clinical Course of Hip and Knee Osteoarthritis in Adults Attending Two Hospital Outpatient Physiotherapy Clinics in NSW: An Evaluation of the Osteoarthritis Chronic Care Program (OACCP).Musculoskeletal care · 2025Article
- Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness.Osteoarthritis and cartilage open · 2025Article
- Decision Analysis in the Management of Hip and Knee Osteoarthritis: A Systematic Review.Cureus · 2025Review
- Health State Utility Values Associated with Knee Osteoarthritis: A Vignette-Based Approach.Patient preference and adherence · 2025Article
- Health literacy status and its relationship with physical therapy and rehabilitation applications in patients with knee osteoarthritis.Turkish journal of physical medicine and rehabilitation · 2024Article
- Cost-Effectiveness of Community-Based Diet and Exercise for Patients with Knee Osteoarthritis and Obesity or Overweight.Arthritis care & research · 2024Article
- Budget impact of the Walk With Ease program for knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Personalized Multimodal Lifestyle Intervention as the Best-Evidenced Treatment for Chronic Pain: State-of-the-Art Clinical Perspective.Journal of clinical medicine · 2024Review
- Walk with ease for knee osteoarthritis: A cost-effectiveness analysis.Osteoarthritis and cartilage open · 2023Article
- Cost-Effectiveness of Weight-Loss Interventions Prior to Total Knee Replacement for Patients With Class III Obesity.Arthritis care & research · 2023Article
- Functional biomaterials for osteoarthritis treatment: From research to application.Smart medicine · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe Intensive Diet and Exercise for Arthritis (IDEA) trial showed that an intensive diet and exercise (D+E) program led to a mean 10.6-kg weight reduction and 51% pain reduction in patients with knee osteoarthritis (OA). The aim of the current study was to investigate the cost-effectiveness of adding this D+E program to treatment in overweight and obese (body mass index >27 kg/m
methodsWe used the Osteoarthritis Policy Model to estimate quality-adjusted life-years (QALYs) and lifetime costs for overweight and obese patients with knee OA, with and without the D+E program. We evaluated cost-effectiveness with the incremental cost-effectiveness ratio (ICER), a ratio of the differences in lifetime cost and QALYs between treatment strategies. We considered 3 cost-effectiveness thresholds: $50,000/QALY, $100,000/QALY, and $200,000/QALY. Analyses were conducted from health care sector and societal perspectives and used a lifetime horizon. Costs and QALYs were discounted at 3% per year. D+E characteristics were derived from the IDEA trial. Deterministic and probabilistic sensitivity analyses (PSAs) were used to evaluate parameter uncertainty and the effect of extending the duration of the D+E program.
resultsIn the base case, D+E led to 0.054 QALYs gained per person and cost $1,845 from the health care sector perspective and $1,624 from the societal perspective. This resulted in ICERs of $34,100/QALY and $30,000/QALY. In the health care sector perspective PSA, D+E had 58% and 100% likelihoods of being cost-effective with thresholds of $50,000/QALY and $100,000/QALY, respectively.
conclusionAdding D+E to usual care for overweight and obese patients with knee OA is cost-effective and should be implemented in clinical practice.
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Registered trials
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