Evidence map›Paper›PMID 30054961›Full record

ReviewAngewandte Chemie (International ed. in English)2019

Chemistry for Positron Emission Tomography: Recent Advances in

Xiaoyun Deng, Jian Rong, Lu Wang, Neil Vasdev, Lei Zhang, Lee Josephson, Steven H Liang

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Recent advances in [Nuclear medicine and biology · 2026
    Review
  4. Article
  5. A Ni-Mediated Cross-Coupling Approach to DeuteratedJournal of the American Chemical Society · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. GHSR-Targeted PET Imaging Probe.ACS medicinal chemistry letters · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Radiosynthesis and Evaluation ofACS medicinal chemistry letters · 2026
    Article
  14. Article
  15. Radiosynthesis and Preclinical Evaluation of a NovelACS medicinal chemistry letters · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Trifluoromethylation of alkyl electrophiles withScience (New York, N.Y.) · 2025
    Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyun DengDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.
Jian RongDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.
Lu WangDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.
Neil VasdevDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.
Lei ZhangMedicine Design, Pfizer Inc., Cambridge, MA, 02139, USA.
Lee JosephsonDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0003-1413-6315

Funding

In vivo Probe for ionotropic glutamate signaling system: AMPA receptorsR01MH120197 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2019 to 2021
$2.4M
Neuro-PET Radiotracer Discovery for Imaging Glycogen Synthase Kinase-3R01AG054473 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VASDEV, NEIL · 2017 to 2020
$1.7M
PET ligand development for mGlu2 based on negative allosteric modulatorsR01MH117125 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2018 to 2020
$1.6M
New PET tracers for neuroimaging of FAAH in endocannabinoid signalingK01DA038000 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2014 to 2018
$927k
Novel PET Tracers for Imaging Monoacylglycerol Lipase in Endocannabinoid SignalingR33DA043507 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2019 to 2021
$851k
Novel PET Tracers for Imaging Monoacylglycerol Lipase in Endocannabinoid SignalingR21DA043507 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2017 to 2018
$425k
fundamental research funds for the central universities 21617311National Natural Science Foundation of China 81701751NIA NIH HHS R01 AG054473NIDA NIH HHS K01 DA038000NIDA NIH HHS R21 DA043507NIDA NIH HHS R33 DA043507NIMH NIH HHS R01 MH117125NIMH NIH HHS R01 MH120197
6 · The paper itself

Abstract

Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron-emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on

Indexed as

Isotope LabelingPositron-Emission TomographyCarbon RadioisotopesFluorine RadioisotopesHumansNitrogen RadioisotopesOxygen RadioisotopesCarbon RadioisotopesFluorine RadioisotopesNitrogen RadioisotopesOxygen Radioisotopescarbon-11fluorine-18nitrogen-13oxygen-15positron emission tomography

Identifiers

PMID30054961
PMCPMC6405341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.