Evidence map›Paper›PMID 30054845›Full record

ReviewJournal of assisted reproduction and genetics2018

Are computational applications the "crystal ball" in the IVF laboratory? The evolution from mathematics to artificial intelligence.

Mara Simopoulou, Konstantinos Sfakianoudis, Evangelos Maziotis, Nikolaos Antoniou, Anna Rapani, George Anifandis, Panagiotis Bakas, Stamatis Bolaris, Agni Pantou, Konstantinos Pantos and 1 more

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07611448 (An Observational Study of Artificial Intelligence-Assisted Blastocyst Morphokinetic Analysis Using Short-Duration Video and Its Association With Pregnancy Outcomes), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07611448 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

An Observational Study of Artificial Intelligence-Assisted Blastocyst Morphokinetic Analysis Using Short-Duration Video and Its Association With Pregnancy Outcomes

Typeobservational_patient_registrySponsorViable BiosciencesRan2026 to 2029Enrolled1,000ConditionsInfertility Assisted Reproductive Technology, Infertility (IVF Patients)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A review of artificial intelligence applications in in vitro fertilization.Journal of assisted reproduction and genetics · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. New frontiers in embryo selection.Journal of assisted reproduction and genetics · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mara SimopoulouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527, Athens, Greece. marasimopoulou@hotmail.com.ORCID http://orcid.org/0000-0002-1000-9100
Konstantinos SfakianoudisCentre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli, 15232, Athens, Greece.
Evangelos MaziotisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527, Athens, Greece.
Nikolaos AntoniouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527, Athens, Greece.
Anna RapaniDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527, Athens, Greece.
George AnifandisDepartment of Histology and Embryology, Faculty of Medicine, University of Thessaly, 3, Panepistimiou, 41500, Larissa, Greece.
Panagiotis BakasAssisted Conception Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528, Athens, Greece.
Stamatis BolarisAssisted Conception Unit, General-Maternity District Hospital "Elena Venizelou", 2, Helena Venizelou Square, 11521, Athens, Greece.
Agni PantouCentre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli, 15232, Athens, Greece.
Konstantinos PantosCentre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli, 15232, Athens, Greece.
Michael KoutsilierisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527, Athens, Greece.
National and Kapodistrian University of Athens · GRGeneral-Maternity District Hospital Helena Venizelou · GRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mathematics rules the world of science. Innovative technologies based on mathematics have paved the way for implementation of novel strategies in assisted reproduction. Ascertaining efficient embryo selection in order to secure optimal pregnancy rates remains the focus of the in vitro fertilization scientific community and the strongest driver behind innovative approaches. This scoping review aims to describe and analyze complex models based on mathematics for embryo selection, devices, and software most widely employed in the IVF laboratory and algorithms in the service of the cutting-edge technology of artificial intelligence. Despite their promising nature, the practicing embryologist is the one ultimately responsible for the success of the IVF laboratory and thus the one to approve embracing pioneering technologies in routine practice. Applied mathematics and computational biology have already provided significant insight into the selection of the most competent preimplantation embryo. This review describes the leap of evolution from basic mathematics to bioinformatics and investigates the possibility that computational applications may be the means to foretell a promising future for the IVF clinical practice.

Indexed as

Artificial IntelligenceBlastocystFemaleFertilization in VitroHumansLaboratoriesMathematicsPregnancyPregnancy RateSoftwareArtificial intelligence IVFBayesian models IVFDevices IVFPrediction models IVFTime-lapse IVF

Identifiers

PMID30054845
PMCPMC6133811
OpenAlexW2884141125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.