ArticleMolecular biology reports2018
IL-17 blood levels increase in healthy pregnancy but not in spontaneous abortion.
Article in Molecular biology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A multi-country, multi-year, meta-analytic evaluation of the sex differences in age-specific pertussis incidence rates.PloS one · 2020Pooled it
- γδ T cell frequencies are altered in HIV positive pregnant South African women and are associated with preterm birth.PloS one · 2020Trial
- Fetal inflammatory signals regulate maternal investment during marsupial pregnancy.PLoS biology · 2026Article
- Investigation of the Relationship Between IL-17, IL-27, IL-2 Blood Levels in Spontaneous Abortion and Healthy Pregnant Women.Life (Basel, Switzerland) · 2025Article
- Dynamic changes in peripheral blood CD4+ T cell subsets are associated with litter performance in primiparous gestating sows.Journal of animal science · 2025Article
- Analysis of the implementation value of abdominal B-ultrasound combined with cervical cerclage in the prevention and treatment of late recurrent spontaneous abortion.BMC pregnancy and childbirth · 2024Article
- Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome.Antioxidants (Basel, Switzerland) · 2024Article
- Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss.International journal of molecular sciences · 2024Review
- Phenotypic changes of γδ T cells inFrontiers in immunology · 2024Article
- Possible Role ofInternational journal of fertility & sterility · 2023Article
- The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses.International journal of molecular sciences · 2022Review
- Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage.Journal of clinical medicine · 2022Article
- Molecular investigation of association between common IL-6 polymorphism with cytomegalovirus (CMV) infection and recurrent miscarriage in Iranian women.Molecular biology reports · 2022Article
- The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature.International journal of molecular sciences · 2022Review
- Article
- Benefits of α-lipoic acid in high-risk pregnancies (Review).Experimental and therapeutic medicine · 2021Review
- The Role of Maternal Immune Activation in the Pathogenesis of Autism: A Review of the Evidence, Proposed Mechanisms and Implications for Treatment.International journal of molecular sciences · 2021Review
- Impact of Th-17 Cytokines on the Regulation of Transporters in Human Placental Explants.Pharmaceutics · 2021Article
- The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study.Cytokine · 2021Article
- TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are essential to maintain and coordinate the correct activity of immune cells during human pregnancy. IL-17 is a pro-inflammatory cytokine that induces the expression of many inflammatory mediators. The aim of this study was to compare the levels of Th1, Th2 and Th17 cytokines of women ongoing normal pregnancy with those found in women who suffered spontaneous abortion. IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, and IFN-γ peripheral blood levels were measured in women who suffered spontaneous abortion (n = 13, blood collected up to 24 h after abortion), and were compared with healthy successful pregnancies (n = 16). Cytokine levels were measured using a cytometric bead array (CBA analysis). Similar cytokine levels were observed between spontaneous abortion and healthy pregnant women excepted to IL-17, which levels were increased in the healthy pregnant women (p = 0.0232). Our results show high IL-17 levels in the peripheral blood of women at late stages of healthy pregnancy, although low IL-17 levels were detected in the peripheral blood of women just after spontaneous abortion. In line with recent studies, this finding highlights IL-17 as a regulatory cytokine essential to the maintenance of a successful pregnancy.
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