Evidence map›Paper›PMID 30054696›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Robot-assisted laparoscopic surgery using DROP-IN radioguidance: first-in-human translation.

Philippa Meershoek, Matthias N van Oosterom, Hervé Simon, Laurent Mengus, Tobias Maurer, Pim J van Leeuwen, Esther M K Wit, Henk G van der Poel, Fijs W B van Leeuwen

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Actionable Feedback on Signal-to-Background Ratios During Drop-in Radioguided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Review
  7. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Molecular image-guided surgery in gynaecological cancer: where do we stand?European journal of nuclear medicine and molecular imaging · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Robot-Assisted Prostate-Specific Membrane Antigen-Radioguided Surgery in Primary Diagnosed Prostate Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  20. Annals of nuclear medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Philippa MeershoekInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center (LUMC), Albinusdreef 2, PO Box 9600, postal zone C2-S, 2300 RC, Leiden, The Netherlands.
Matthias N van OosteromInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center (LUMC), Albinusdreef 2, PO Box 9600, postal zone C2-S, 2300 RC, Leiden, The Netherlands.
Hervé Simon, Eurorad S.A., 2 rue Ettore Bugatti, 67201, Eckbolsheim, France.
Laurent Mengus, Eurorad S.A., 2 rue Ettore Bugatti, 67201, Eckbolsheim, France.
Tobias MaurerDepartment of Urology, Technical University of Munich, Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.
Pim J van LeeuwenDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Esther M K WitDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Henk G van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Fijs W B van LeeuwenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center (LUMC), Albinusdreef 2, PO Box 9600, postal zone C2-S, 2300 RC, Leiden, The Netherlands. F.W.B.van_Leeuwen@lumc.nl.ORCID http://orcid.org/0000-0002-6844-4025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRadioguided surgery has been widely used for clinical procedures such as sentinel node resections. In the (robot-assisted) laparoscopic setting radioguidance is realized using laparoscopic gamma probes, which have limited maneuverability. To increase the rotational freedom, a tethered DROP-IN gamma probe was designed. Here we present the first in vivo feasibility study of this technology in prostate cancer patients.

methodsTen patients scheduled for a sentinel node procedure received four injections into the prostate with (indocyanine green-)

resultsThe sentinel nodes were resected using the da Vinci® Si robot under guidance of DROP-IN gamma tracing and fluorescence imaging. The surgeon was able to independently maneuver the DROP-IN probe using the ProGrasp® forceps of the da Vinci® robot and distinguish sentinel nodes from background signal (such as the injection site).

conclusionsOverall the DROP-IN design proves to be a valuable tool for robot-assisted radioguided surgery approaches.

Indexed as

Single Photon Emission Computed Tomography Computed TomographyAgedHumansIndocyanine GreenLaparoscopyMaleMiddle AgedProstatic NeoplasmsRadiopharmaceuticalsRobotic Surgical ProceduresSentinel Lymph NodeTechnetiumIndocyanine GreenRadiopharmaceuticalsTechnetiumGamma probeProstate cancerRadioguided surgeryRobotic surgerySentinel lymph node

Identifiers

PMID30054696
PMCPMC6267681

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.