ArticleThe Journal of experimental medicine1986
Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils.
Article in The Journal of experimental medicine, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 139 citations in OpenAlex.
- The formation and function of the neutrophil phagosome.Immunological reviews · 2023Review
- Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fcγ Receptors.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Neutralizing and non-neutralizing monoclonal antibodies against dengue virus E protein derived from a naturally infected patient.Virology journal · 2010Article
- Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.Clinical and experimental immunology · 2000Article
- The high-affinity Fc gamma RI on PMN: regulation of expression and signal transduction.Immunology · 1997Article
- Role for a glycan phosphoinositol anchor in Fc gamma receptor synergy.The Journal of cell biology · 1997Article
- Allergen-specific IgG1 and IgG3 through Fc gamma RII induce eosinophil degranulation.The Journal of clinical investigation · 1995Article
- Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.The Journal of clinical investigation · 1995Article
- IgM monoclonal antibodies recognizing Fc alpha R but not Fc gamma RIII trigger a respiratory burst in neutrophils although both trigger an increase in intracellular calcium levels and degranulation.The Biochemical journal · 1995Article
- Article
- CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.The Journal of cell biology · 1994Article
- Fc receptor-mediated signal transduction.Journal of clinical immunology · 1994Review
- Fc gamma RI and Fc gamma RIII on polymorphonuclear leucocytes in cord blood.Archives of disease in childhood. Fetal and neonatal edition · 1994Article
- Neutrophil Fc receptor participation in phagocytosis of type III group B streptococci.Infection and immunity · 1993Article
- Enhancement of the antibody-dependent cellular cytotoxicity of human peripheral blood lymphocytes with interleukin-2 and interferon alpha.Cancer immunology, immunotherapy : CII · 1993Article
- Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.The Journal of clinical investigation · 1992Article
- Fc receptors for IgG (Fc gamma Rs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-1): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including the Fc gamma R.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Expression of IgG Fc receptor antigens in placenta and on endothelial cells in humans. An immunohistochemical study.The American journal of pathology · 1991Article
- Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins.The Journal of clinical investigation · 1991Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We describe a newly recognized 40 kD FcR for IgG on human neutrophilic granulocytes. An mAb (IV3) developed against the IgG FcR of K562 cells, and specific as well for a 40 kD FcR on human monocytes and platelets, was found to purify by affinity adsorption a 40 kD protein from detergent lysates of surface-radioiodinated neutrophils. This protein, proteolytically degraded to 33 kD when purified in the absence of diisopropylfluorophosphate, is distinct from the 51-73 kD protein precipitated by the anti-neutrophil FcR mAb, 3G8, previously described by others. Complete inhibition of binding of rabbit IgG-coated erythrocytes to neutrophils was achieved only when both antibodies, IV3 and 3G8, were used. Fab fragments of IV3 were as effective inhibitors as the intact molecule. IV3 IgG or Fab fragments completely and selectively inhibited immune complex-mediated generation of superoxide by human neutrophils; superoxide generation by other stimulants was not abrogated by IV3. This antibody (IV3) bound also to human eosinophils and completely inhibited the binding of IgG-coated erythrocytes to eosinophils. IV3 appears to define the human homolog of the murine macrophage FcRII identified initially by mAb 2.4G2 and present in the mouse on both neutrophils and eosinophils.
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