Evidence map›Paper›PMID 30054580›Full record

ArticleScientific reports2018

Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population.

Brian A Derstine, Sven A Holcombe, Brian E Ross, Nicholas C Wang, Grace L Su, Stewart C Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 290 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
290citing papers in PubMed, 7 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

290 citing papers in PubMed, 7 syntheses or guidelines pooled it, 472 citations in OpenAlex.

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  9. Article
  10. CT-based body composition enhances prognostic performance of PASO score for surgical outcome in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  11. Article
  12. CT-defined sarcopenia as a predictor of early mortality following hip fracture: a retrospective cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
    Article
  13. Article
  14. Future of CT body composition research: Methodological discrepancies and advances.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
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230 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brian A DerstineMorphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA. bderstin@med.umich.edu.ORCID 0000-0002-2869-9584
Sven A HolcombeMorphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA.
Brian E RossMorphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA.
Nicholas C WangMorphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA.
Grace L SuMorphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA.
Stewart C WangMorphomic Analysis Group, University of Michigan, Ann Arbor, MI, USA.
Morpho (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' values are used. Conventionally, cutoffs for skeletal muscle measurements at the level of the third lumbar (L3) vertebra are used, however L3 is not included in several clinical CT protocols. Non-contrast-enhanced CT scans from healthy kidney donor candidates (age 18-40) at Michigan Medicine were utilized. Skeletal muscle area (SMA), index (SMI), and mean attenuation (SMRA) were measured at each vertebral level between the tenth thoracic (T10) and the fifth lumbar (L5) vertebra. Sex-specific means, standard deviations (s.d.), and sarcopenia cutoffs (mean-2 s.d.) at each vertebral level were computed. Associations between vertebral levels were assessed using Pearson correlations and Tukey's difference test. Classification agreement between different vertebral level cutoffs was assessed using overall accuracy, specificity, and sensitivity. SMA, SMI, and SMRA L3 cutoffs for sarcopenia were 92.2 cm

Indexed as

AdultFemaleHumansLumbar VertebraeMaleMuscle, SkeletalReference ValuesSarcopeniaSex FactorsThoracic VertebraeTomography, X-Ray ComputedUnited States

Identifiers

PMID30054580
PMCPMC6063941
OpenAlexW2883061070

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.