Evidence map›Paper›PMID 30054570›Full record

ReviewNature reviews. Neuroscience2018

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man.

Robert J Fenster, Lauren A M Lebois, Kerry J Ressler, Junghyup Suh

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05544110 (Study on the Effect and Mechanism of Individualized and Precise Location Transcranial Magnetic Stimulation Based on Magnetic Resonance Imaging on Post-traumatic Stress Disorder), which is not on this map. Cited by 263 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
263citing papers in PubMed, 7 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05544110 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Study on the Effect and Mechanism of Individualized and Precise Location Transcranial Magnetic Stimulation Based on Magnetic Resonance Imaging on Post-traumatic Stress Disorder

TypeinterventionalSponsorXijing HospitalRan2023 to 2025Enrolled66ConditionsPTSDArmsActive transcranial magnetic stimulation, Sham transcranial magnetic stimulation
3 · Its place in the literature

Who cites it

263 citing papers in PubMed, 7 syntheses or guidelines pooled it, 440 citations in OpenAlex.

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203 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Robert J FensterDivision of Depression and Anxiety Disorders, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
Lauren A M LeboisDivision of Depression and Anxiety Disorders, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
Kerry J ResslerDivision of Depression and Anxiety Disorders, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. kressler@mclean.harvard.edu.
Junghyup SuhDivision of Depression and Anxiety Disorders, McLean Hospital Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. jsuh@mclean.harvard.edu.
Harvard University · USMcLean Hospital · US

Funding

Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
Site 3/3, Understanding PTSD through Postmortem Targeted Brain MultiomicsR01MH117292 · NIMH · MCLEAN HOSPITAL · PI Nikolaos Daskalakis, KERRY J. RESSLER · 2018 to 2026
$5.0M
2 of 2 Prospective Determination of Psychobiological Risk Factors for PTSDR01MH094757 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2012 to 2016
$2.3M
Neurobiology of Traumatic Dissociation in a Transdiagnostic Study of Women with Childhood MaltreatmentR21MH112956 · NIMH · MCLEAN HOSPITAL · PI KAUFMAN, MILISSA L · 2017 to 2018
$446k
Neural circuit mechanisms of stress-induced alcohol seeking behaviorR21AA027450 · NIAAA · MCLEAN HOSPITAL · PI RESSLER, KERRY J., SUH, JUNGHYUP · 2019 to 2020
$431k
Neurobiology of Self-Referential Processing in Posttraumatic Stress Disorder Dysfunction and RecoveryF32MH109274 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2016 to 2018
$174k
NIAAA NIH HHS R21 AA027450NIMH NIH HHS F32 MH109274NIMH NIH HHS R01 MH094757NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH117292NIMH NIH HHS R21 MH112956
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.

Indexed as

AnimalsBrainDisease Models, AnimalHumansMiceNeural PathwaysNeuronsStress Disorders, Post-Traumatic

Identifiers

PMID30054570
PMCPMC6148363
OpenAlexW2884319195

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.