Evidence map›Paper›PMID 30054495›Full record

ArticleScientific reports2018

Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes.

Aric F Logsdon, James S Meabon, Marcella M Cline, Kristin M Bullock, Murray A Raskind, Elaine R Peskind, William A Banks, David G Cook

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 93 citations in OpenAlex.

  1. Nitric oxide and traumatic brain injury.Medical gas research · 2027
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Aric F LogsdonGeriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
James S MeabonVeterans Affairs Northwest Network, Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Marcella M ClineGeriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Kristin M BullockGeriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Murray A RaskindVeterans Affairs Northwest Network, Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Elaine R PeskindVeterans Affairs Northwest Network, Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
William A BanksGeriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
David G CookGeriatric Research Education and Clinical Center (GRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA. dgcook@u.washington.edu.
Geriatric Research Education and Clinical Center · USVA Northwest Network · USBehavioral Tech Research, Inc. · USSeattle University · USUniversity of Puget Sound · USUniversity of Washington · US

Funding

Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Intranasal Insulin in a Mouse Model of Alzheimer's DiseaseR01AG046619 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI BANKS, WILLIAM A · 2014 to 2018
$2.4M
The role of glia dysfunction in the neurodegenerative processes induced by blastI01BX002311 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI COOK, DAVID G · 2014 to 2021
–
Mild TBI and Biomarkers of NeurodegenerationI01RX001612 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI PESKIND, ELAINE R. · 2015 to 2018
–
BLRD VA I01 BX002311NIA NIH HHS R01 AG046619NIA NIH HHS T32 AG052354RRD VA I01 RX001612U.S. Department of Veterans Affairs (VA) RDIS #0005
6 · The paper itself

Abstract

Mild blast-induced traumatic brain injury (TBI) is associated with blood-brain barrier (BBB) disruption. However, the mechanisms whereby blast disrupts BBB integrity are not well understood. To address this issue BBB permeability to peripherally injected

Indexed as

AlbuminsAnimalsBlast InjuriesBlood-Brain BarrierBrain Injuries, TraumaticCarbon RadioisotopesClaudin-5Cyclooxygenase InhibitorsGliosisMaleMice, Inbred C57BLNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOrgan SpecificityPermeabilityAlbuminsCarbon-14Carbon RadioisotopesClaudin-5Cyclooxygenase InhibitorsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseRadiopharmaceuticalsSucroseTumor Necrosis Factor-alpha

Identifiers

PMID30054495
PMCPMC6063850
OpenAlexW2884877816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.