Evidence map›Paper›PMID 30054483›Full record

ArticleNature communications2018

A user-friendly herbicide derived from photo-responsive supramolecular vesicles.

Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P M Hoi, Jianxiang Zhang, Simon M Y Lee, Ruibing Wang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 162 citations in OpenAlex.

  1. Article
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  11. Review
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  13. Article
  14. Amphiphilic Cationic Carbon Dots for Efficient Delivery of Light-Dependent Herbicide.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  15. Biomimetic Entropy-Dominant Molecular Hinges with Picomolar Affinity.Journal of the American Chemical Society · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Cucurbit[8]uril-based supramolecular theranostics.Journal of nanobiotechnology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Cheng GaoState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Qiaoxian HuangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Qingping LanState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Yu FengState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Fan TangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Maggie P M HoiState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Jianxiang ZhangDepartment of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Simon M Y LeeState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. simonlee@umac.mo.
Ruibing WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. rwang@umac.mo.ORCID http://orcid.org/0000-0001-9489-4241
University of Macau · MOArmy Medical University · CN

Funding

Universidade de Macau (University of Macau) MYRG2016-00133-ICMS-QRCM, MYRG2016-00165-ICMS-QRCM and MYRG2016-00008-ICMS-QRCM
6 · The paper itself

Abstract

Paraquat, as one of the most widely used herbicides globally, is highly toxic to humans, and chronic exposure and acute ingestion leads to high morbidity and mortality rates. Here, we report user-friendly, photo-responsive paraquat-loaded supramolecular vesicles, prepared via one-pot self-assembly of amphiphilic, ternary host-guest complexes between cucurbit[8]uril, paraquat, and an azobenzene derivative. In this vesicle formulation, paraquat is only released upon UV or sunlight irradiation that converts the azobenzene derivative from its trans- to its cis- form, which in turn dissociates the ternary host-guest complexations and the vesicles. The cytotoxicity evaluation of this vesicle formulation of paraquat on in vitro cell models, in vivo zebrafish models, and mouse models demonstrates an enhanced safety profile. Additionally, the PQ-loaded vesicles' herbicidal activity against a model of invasive weed is nearly identical to that of free paraquat under natural sunlight. This study provides a safe yet effective herbicide formulation.

Indexed as

AnimalsAzo CompoundsChlorocebus aethiopsCOS CellsFemaleHerbicidesHumansKidneyLiverMiceMice, Inbred C57BLModels, AnimalParaquatZebrafishazobenzeneAzo CompoundsHerbicidesParaquat

Identifiers

PMID30054483
PMCPMC6063903
OpenAlexW2883595277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.