Evidence map›Paper›PMID 30054450›Full record

ArticleThe Journal of cell biology2018

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.

Marianne de la Roche, Claire Hamilton, Rebecca Mortensen, A Arockia Jeyaprakash, Sanjay Ghosh, Paras K Anand

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis.American journal of respiratory cell and molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marianne de la RocheInfectious Diseases and Immunity, Department of Medicine, Imperial College London, London, UK.
Claire HamiltonInfectious Diseases and Immunity, Department of Medicine, Imperial College London, London, UK.
Rebecca MortensenInfectious Diseases and Immunity, Department of Medicine, Imperial College London, London, UK.
A Arockia JeyaprakashWellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-1889-8635
Sanjay GhoshDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Paras K AnandInfectious Diseases and Immunity, Department of Medicine, Imperial College London, London, UK paras.anand@imperial.ac.uk.ORCID 0000-0003-2503-3653
Imperial College London · GBUniversity of Cambridge · GBWellcome Centre for Cell Biology · GB

Funding

Wellcome Trust 108248/Z/15/ZWellcome Trust 202811Wellcome Trust 202811/Z/16/Z
6 · The paper itself

Abstract

Cellular lipids determine membrane integrity and fluidity and are being increasingly recognized to influence immune responses. Cellular cholesterol requirements are fulfilled through biosynthesis and uptake programs. In an intricate pathway involving the lysosomal cholesterol transporter NPC1, the sterol gets unequally distributed across intracellular compartments. By using pharmacological and genetic approaches targeting NPC1, we reveal that blockade of cholesterol trafficking through the late endosome-lysosome pathway blunts NLRP3 inflammasome activation. Altered cholesterol localization at the plasma membrane (PM) in

Indexed as

Signal TransductionAnimalsBiological Transport, ActiveCell MembraneCholesterolDNA-Binding ProteinsEndoplasmic ReticulumInflammasomesIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutNiemann-Pick C1 ProteinNLR Family, Pyrin Domain-Containing 3 ProteinProteinsProto-Oncogene Proteins c-aktToll-Like Receptor 4Aim2 protein, mouseCholesterolDNA-Binding ProteinsInflammasomesIntracellular Signaling Peptides and ProteinsmTOR protein, mouseNiemann-Pick C1 ProteinNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseNpc1 protein, mouseProteinsProto-Oncogene Proteins c-aktTlr4 protein, mouseToll-Like Receptor 4TOR Serine-Threonine Kinases

Identifiers

PMID30054450
PMCPMC6168277
OpenAlexW2884888151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.