ArticleBioscience reports2018
Analysis of anti-osteoporosis function of chlorogenic acid by gene microarray profiling in ovariectomy rat model.
Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Therapeutic Effects of the Most Common Polyphenols Found inNutrients · 2026Review
- Characterization and preparation of food-derived peptides on improving osteoporosis: A review.Food chemistry: X · 2024Article
- Osteogenic mechanism of chlorogenic acid and its application in clinical practice.Frontiers in pharmacology · 2024Review
- Secoisolariciresinol diglucoside regulates estrogen receptor expression to ameliorate OVX-induced osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Comparative Pharmacokinetic Study of 5 Active Ingredients after Oral Administration of Zuogui Pill in Osteoporotic Rats with Different Syndrome Types.International journal of analytical chemistry · 2023Article
- GC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark.Scientific reports · 2022Article
- Article
- Kaempferol promotes bone formation in part via the mTOR signaling pathway.Molecular medicine reports · 2019Article
- Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to clarify the effect of chlorogenic acid (CGA) on estrogen deficiency-induced osteoporosis based on micro-computed tomography (micro-CT) and potential mechanism of gene regulation via microarray profiling. Eighteen female Sprague-Dawley rats were divided randomly into sham-operated group, ovariectomy (OVX) plus saline vehicle group, and OVX plus CGA treatment group (CGA at 45 mg/kg/day). The loss of bone mass of the femoral metaphysis was evaluated by micro-CT to represent. Gene expression profiling was analyzed for bone marrow mesenchymal stem cells (BMSCs) of OVX and OVXT groups. Bioinformatics analysis was used to find the potential pathways regulated by CGA. OVX-induced osteoporosis could decrease femur bone mineral density (BMD), bone volume/tissue volume (BV/TV), trabecula number (Tb.N), and trabecular thickness (Tb.Th) and increased the trabecular separation (Tb.Sp) and structure model index (SMI) in the rats. Gene microarray profiling showed 121 differentially expressed genes in collected BMSCs between OVX and OVXT groups were identified with a threshold of a two-fold change and
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