Evidence map›Paper›PMID 30054307›Full record

Trial reportBlood advances2018

Validation of the 2017 revision of the WHO chronic myelomonocytic leukemia categories.

Sanam Loghavi, Dawen Sui, Peng Wei, Guillermo Garcia-Manero, Sherry Pierce, Mark J Routbort, Elias J Jabbour, Naveen Pemmaraju, Rashmi Kanagal-Shamanna, H Deniz Gur and 5 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05933070 (A Phase I Open-Label Dose Escalation Study Of Intravenous INKmune In Patients With Myelodysplastic Syndrome With Excess Blasts), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05933070 phase1terminatednot on this mapstarted 2020, after this paper: background citation

A Phase I Open-Label Dose Escalation Study Of Intravenous INKmune In Patients With Myelodysplastic Syndrome With Excess Blasts (MDS-EB-1/2 - MDS-CMML 1/2) Or Acute Myeloid Leukaemia (AML)

TypeinterventionalSponsorInmune Bio, Inc.Ran2020 to 2024Enrolled2ConditionsCancer, MDS-EB, Myelodysplastic Syndromes, Acute Myeloid LeukemiaArmsINKmune
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Chronic Myelomonocytic Leukemia: Hematopathology Perspective.Journal of immunotherapy and precision oncology · 2021
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Update on the pathologic diagnosis of chronic myelomonocytic leukemia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sanam LoghaviDepartment of Hematopathology.ORCID 0000-0001-8980-3202
Dawen SuiDepartment of Biostatistics, and.
Peng WeiDepartment of Biostatistics, and.
Guillermo Garcia-ManeroDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-3631-2482
Sherry PierceDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Mark J RoutbortDepartment of Hematopathology.ORCID 0000-0003-4860-261X
Elias J JabbourDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0003-4465-6119
Naveen PemmarajuDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-1670-6513
Rashmi Kanagal-ShamannaDepartment of Hematopathology.ORCID 0000-0001-7829-5249
H Deniz GurDepartment of Hematopathology.
Shimin HuDepartment of Hematopathology.ORCID 0000-0001-7110-3814
Zhuang ZuoDepartment of Hematopathology.
L Jeffrey MedeirosDepartment of Hematopathology.ORCID 0000-0001-6577-8006
Hagop M KantarjianDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-1908-3307
Joseph D KhouryDepartment of Hematopathology.ORCID 0000-0003-2621-3584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2017 revision of the World Health Organization (WHO) classification includes substantial changes to the subclassification of chronic myelomonocytic leukemia (CMML): (1) a 3-tiered blast-based scheme including a novel "CMML-0" category replacing a 2-tiered system in place since 2001 and (2) 2 CMML subtypes, myelodysplastic (MDS-CMML) and myeloproliferative (MP-CMML), based on a white blood cell count cutoff of 13 × 10

Indexed as

AdultAgedAged, 80 and overBlast CrisisDisease-Free SurvivalFemaleHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleMiddle AgedRisk AssessmentSurvival RateWorld Health Organization

Identifiers

PMID30054307
PMCPMC6093727

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.