Evidence map›Paper›PMID 30054282›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

[

Eline E Verwer, Taylor R Kavanagh, William J Mischler, You Feng, Kazue Takahashi, Shuyan Wang, Timothy M Shoup, Ramesh Neelamegam, Jing Yang, Nicolas J Guehl and 10 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Novel treatment strategies for lymphangioleiomyomatosis: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  4. Review
  5. Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Eline E VerwerGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-0799-8614
Taylor R Kavanagh *Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
William J Mischler *Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
You FengPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Kazue TakahashiGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Shuyan WangRadiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Timothy M ShoupGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Ramesh NeelamegamGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Jing YangMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Nicolas J GuehlGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Chongzhao RanMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Walter MassefskiDana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Ye CuiPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Souheil El-ChemalyPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Peter M SadowDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-1036-6367
William M OldhamPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-3029-4866
Marie F KijewskiRadiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Carmen PrioloPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. cpriolo@partners.org.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Targeting Choline Phospholipid Metabolism in LymphangioleiomyomatosisR01HL130336 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PRIOLO, CARMEN · 2016 to 2020
$2.2M
Regulation of pulmonary vascular cell redox state by L-2-hydroxyglutarateK08HL128802 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OLDHAM, WILLIAM MICHAEL · 2016 to 2020
$862k
NHLBI NIH HHS K08 HL128802NHLBI NIH HHS R01 HL130336NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

purposeTuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by inactivating mutations of the EXPERIMENTAL

designThese preclinical studies aimed to assess feasibility of [

resultsWe previously reported that TSC2-deficient cells enhance phosphatidylcholine synthesis via the Kennedy pathway. Here, we show that TSC2-deficient cells exhibit rapid uptake of [

conclusionsPreclinical models of TSC2 deficiency represent informative platforms to identify tracers of potential clinical interest. Our findings provide mechanistic evidence for testing the potential of [

Indexed as

Positron-Emission TomographyAgedAnimalsBiomarkersCholineDisease Models, AnimalFemaleFluoroacetatesHeterograftsHumansImage Processing, Computer-AssistedImmunohistochemistryLipid MetabolismLymphangioleiomyomatosisMaleMiceBiomarkersCholineFluoroacetatesfluorocholinePhosphatidylcholines

Identifiers

PMID30054282
PMCPMC6816044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.