Evidence map›Paper›PMID 30054272›Full record

ArticleThe Journal of biological chemistry2018

Role of a conserved glutamine in the function of voltage-gated Ca

Edgar Garza-Lopez, Josue A Lopez, Jussara Hagen, Ruth Sheffer, Vardiella Meiner, Amy Lee

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Patient-specific induced pluripotent stem cell properties implicate CaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  4. CACNA1D-Related Channelopathies: From Hypertension to Autism.Handbook of experimental pharmacology · 2023
    Review
  5. Whole Exome Sequencing Identifies a Heterozygous Variant in the Cav1.3 GeneInternational journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
  8. De novo CACNA1D CaPflugers Archiv : European journal of physiology · 2020
    Review
  9. Article
  10. Article
  11. Biophysical classification of aMolecular autism · 2020
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Edgar Garza-LopezFrom the Departments of Molecular Physiology and Biophysics, Otolaryngology Head-Neck Surgery, and Neurology and Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242 and.
Josue A LopezFrom the Departments of Molecular Physiology and Biophysics, Otolaryngology Head-Neck Surgery, and Neurology and Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242 and.
Jussara HagenFrom the Departments of Molecular Physiology and Biophysics, Otolaryngology Head-Neck Surgery, and Neurology and Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242 and.
Ruth ShefferDepartment of Genetics and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Vardiella MeinerDepartment of Genetics and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Amy LeeFrom the Departments of Molecular Physiology and Biophysics, Otolaryngology Head-Neck Surgery, and Neurology and Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242 and amy-lee@uiowa.edu.ORCID 0000-0001-8021-0443
University of Iowa · USHadassah Medical Center · IL

Funding

Regulation of auditory calcium channelsR01DC009433 · NIDCD · UNIVERSITY OF IOWA · PI LEE, AMY · 2009 to 2018
$3.6M
Regulation of Neuronal Calcium ChannelsR01NS084190 · NINDS · UNIVERSITY OF IOWA · PI LEE, AMY · 2014 to 2018
$2.2M
Regulation of auditory calcium channelsR55DC009433 · NIDCD · EMORY UNIVERSITY · PI LEE, AMY · 2008 to 2008
$100k
NIDCD NIH HHS R01 DC009433NIDCD NIH HHS R55 DC009433NINDS NIH HHS R01 NS084190
6 · The paper itself

Abstract

Voltage-gated Ca

Indexed as

MutationAmino Acid SequenceCalcium Channels, L-TypeCalcium SignalingConserved SequenceExome SequencingGlutamineGlycineHearing LossHistidineHumansIntellectual DisabilityIon Channel GatingSequence Homology, Amino AcidSynaptic TransmissionCACNA1D protein, humanCalcium Channels, L-TypeGlutamineGlycineHistidineautismCa2+ channelCACNA1Dcalcium channelcalcium voltage-gated channel subunit alpha1 Depilepsygatinghearing impairmentinactivationintellectual disabilityion channelmodulation

Identifiers

PMID30054272
PMCPMC6139563
OpenAlexW2884234337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.