ArticleImmunity2018
PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.
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Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
5.8field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 126 citations in OpenAlex.
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A.Cell death & disease · 2026Article
- PSMD1 inhibition suppresses tumor progression and enhances antitumor immunity by modulating the RTKN/β-catenin/PD-L1 axis in hepatocellular carcinoma.Cell death & disease · 2026Article
- PD-1 receptor deficiency enhances CD30Nature immunology · 2025Article
- Resistance to anti-PD-1 therapy is driven by CD30Nature immunology · 2025Article
- Enhanced antitumor efficacy of bispecific antibody blocking PD-L1 and LAG-3 with doxorubicin: mechanism and safety evaluation.Breast cancer research and treatment · 2025Article
- Regulatory T cells in the tumor microenvironment display a unique chromatin accessibility profile.ImmunoHorizons · 2025Article
- Flow cytometry immune profiling of recurrent and newly diagnosed growth hormone secreting pituitary neuroendocrine tumors: comparison of two clinical cases.BMC endocrine disorders · 2025Article
- Article
- Review
- Steroid-Refractory Myocarditis Induced by Immune Checkpoint Inhibitor Responded to Infliximab: Report of Two Cases and Literature Review.Cardiovascular toxicology · 2024Review
- Limitations and potential strategies of immune checkpoint blockade in age-related neurodegenerative disorders.The journal of physiological sciences : JPS · 2024Review
- mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment.Immunologic research · 2024Article
- Overview of multifunctional Tregs in cardiovascular disease: From insights into cellular functions to clinical implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Review
- Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy.Journal of neuro-oncology · 2024Article
- Legumain Regulates Regulatory T Cells in Hypertension.Circulation research · 2024Article
- A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer.Cancer immunology research · 2023Article
- Chemical Tools to Image the Activity of PAR-Cleaving Proteases.ACS bio & med chem Au · 2023Review
- Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategies.Cellular & molecular immunology · 2023Review
- PDL1 shapes the classical Hodgkin lymphoma microenvironment without inducing T-cell exhaustion.Haematologica · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 11 institutions in 4 countries.
Chaido StathopoulouBio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Arunakumar GangaplaraLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Grace MallettBio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Francis A FlomerfeltExperimental Transplantation Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Lukasz P LinianyBio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
David KnightBiological Mass Spectrometry Core, University of Manchester, Manchester M13 9PL, UK.
Leigh A SamselFlow Cytometry Core, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
Rolando Berlinguer-PalminiBio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Joshua J YimSchool of Medicine, Stanford University, Stanford, CA 94305, USA.
Tania C FelizardoExperimental Transplantation Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Michael A EckhausDivision of Veterinary Resources, Office of Research Services, NIH, Bethesda, MD 20892, USA.
Laura Edgington-MitchellSchool of Medicine, Stanford University, Stanford, CA 94305, USA; Drug Discovery Biology, Monash University, Melbourne, VIC 3800, Australia.
Jonathan Martinez-FabregasCollege of Life Sciences, University of Dundee, Dundee DD1 4HN, UK.
Jinfang ZhuLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Daniel H FowlerExperimental Transplantation Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Sander I van KasterenLeiden Institute of Chemistry and Institute of Chemical Immunology, Leiden University, 2311 EZ Leiden, the Netherlands.
Arian LaurenceBio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Translational Gastroenterology Unit, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, Headington, Oxford OX3 9DU, UK; Department of Haematology, Northern Centre for Cancer Care, Newcastle upon Tyne NE2 4HH, UK.
Matthew BogyoSchool of Medicine, Stanford University, Stanford, CA 94305, USA.
Colin WattsCollege of Life Sciences, University of Dundee, Dundee DD1 4HN, UK.
Ethan M ShevachLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Shoba AmarnathBio-Imaging Unit, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address: shoba.amarnath@newcastle.ac.uk.
Newcastle University · GBNational Cancer Institute · USNational Institute of Allergy and Infectious Diseases · USStanford University · USUniversity of Dundee · GBLeiden University · NLMonash University · AUNational Heart Lung and Blood Institute · USOffice of Research Services · USUniversity of Manchester · GBUniversity of Oxford · GB
Funding
Role of T Regulatory Cells in Chronic InfectionZIAAI001045 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHEVACH, ETHAN · 2009 to 2021
$5.8MAcademy of Medical Sciences SBF003\1129Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA AI001045Medical Research CouncilWellcome Trust
Abstract
CD4
Indexed as
AnimalsCell DifferentiationCells, CulturedColitisCysteine EndopeptidasesFemaleForkhead Transcription FactorsGraft vs Host DiseaseLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMelanoma, ExperimentalMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 Receptorasparaginyl endopeptidase, lysosomalCysteine EndopeptidasesForkhead Transcription FactorsFoxp3 protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorAEPcolitisFoxp3GvHDiTregLCMVmelanomaPD-1PDL-1
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.