Evidence map›Paper›PMID 30054193›Full record

ArticleAcademic radiology2019

Applications of Out of Body Lung Perfusion.

Bing Zhu, Yoshikazu Suzuki, Thomas DiSanto, Samantha Rubin, Zachary Penfil, Ralph A Pietrofesa, Shampa Chatterjee, Melpo Christofidou-Solomidou, Edward Cantu

Abstract read
In one paragraph

Article in Academic radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Early Graft Dysfunction after Lung Transplantation.Current pulmonology reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bing ZhuDivision of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China.
Yoshikazu SuzukiDivision of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Thomas DiSantoDivision of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Samantha RubinDivision of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Zachary PenfilDivision of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Ralph A PietrofesaPulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Shampa ChatterjeeDepartment of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Melpo Christofidou-SolomidouPulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Edward CantuDivision of Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address: edward.cantu@uphs.upenn.edu.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Environmental Science Project 3 - Social Determinants of Risk and Attitudes AboutP42ES023720 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI BLAIR, IAN ALEXANDER · 2014 to 2018
$11.3M
Secoisolariciresinol Diglucoside (SDB) Protection in Radiation PheumonopathyR01CA133470 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOFIDOU-SOLOMIDOU, MELPO · 2008 to 2012
$2.2M
Lung Transplant donor: prediction, evaluation, and mechanismK23HL116656 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CANTU, EDWARD · 2013 to 2017
$872k
NOVEL SYNTHETIC SDG TO TREAT TRAUMA-INDUCED INFLAMMATIONR21AT008291 · NCCIH · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOFIDOU-SOLOMIDOU, MELPO, WINKELSTEIN, BETH A · 2015 to 2016
$440k
Advanced diagnostics for donor lung assessment and ex vivo lung perfusion candidate selectionR03HL135227 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CANTU, EDWARD · 2016 to 2017
$161k
NCCIH NIH HHS R21 AT008291NCI NIH HHS R01 CA133470NHLBI NIH HHS K23 HL116656NHLBI NIH HHS R03 HL135227NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P42 ES023720
6 · The paper itself

Abstract

RATIONALE AND

objectivesOut of body organ perfusion is a concept that has been around for a long time. As technology has evolved, so have the systems available for out of body perfusion making whole organ preservation for extended evaluation, resuscitation, and discovery routine. MATERIALS AND

methodsClinical use of ex vivo lung perfusion (EVLP) systems has continued to expand as evidence has accumulated to suggest EVLP transplants experience similar mortality, ICU length of stay, length of mechanical ventilation, hospital length of stay, and rates of primary graft dysfunction as conventional lung transplants. In 2017, more lung transplants were performed than any previous year in the US history.

resultsEarly success of EVLP has motivated groups to evaluate additional donor types and methods for expanding the donor pool. The ability to keep a lung alive in a physiologically neutral environment opens the ability to better understand organ quality, define pathophysiology in certain disease conditions, and provides a platform for interventions to prevent or repair injury.

conclusionThe next several years will usher in significant changes in understanding and interventions focused on lung injury. This manuscript highlights applications of EVLP to clarify how this system can be used for basic and translational research.

Indexed as

Extracorporeal CirculationLung TransplantationHumansLungOrgan PreservationPerfusionTranslational Research, BiomedicalEx vivo lung perfusionLung transplantation

Identifiers

PMID30054193
PMCPMC6345618

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.