ArticleTrends in neurosciences2018
Exercise Your Kynurenines to Fight Depression.
Article in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies.Wellcome open research · 2023Article
- The Organ of Vision and the Stomatognathic System-Review of Association Studies and Evidence-Based Discussion.Brain sciences · 2021Review
- Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat.Scientific reports · 2021Article
- The Effects and Mechanisms of Exercise on the Treatment of Depression.Frontiers in psychiatry · 2021Review
- Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster.Nature communications · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Kynurenines, the major degradative products of the essential amino acid tryptophan, may play critical roles in the pathophysiology of depressive disorders. In 2014, Agudelo and colleagues reported that exercise indirectly modulates the metabolism of kynurenines in skeletal muscle, which in turn influences the brain and enhances resilience to depression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.