ArticleVeterinary research2018
Different lesion distribution in calves orally or intratracheally challenged with Mycobacterium bovis: implications for diagnosis.
Article in Veterinary research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Prevalence of tuberculosis in bovines in Pakistan during 2000-2024: a systematic review and meta-analysis.Frontiers in veterinary science · 2025Pooled it
- An Examination of Gross Lesions Associated with Bovine Tuberculosis in the U.S.Pathogens (Basel, Switzerland) · 2026Article
- Congenital Tuberculosis in a Stillborn Calf.Pathogens (Basel, Switzerland) · 2026Article
- Apparent prevalence, lesion distribution and risk factors of bovine tuberculosis in cattle slaughtered at the Shashemene and Arsi Negelle municipal abattoirs, Ethiopia.One health (Amsterdam, Netherlands) · 2025Article
- Tuberculosis vaccination: microbiological and immunological summary of a series of experimental challenge studies.Veterinary research · 2025Article
- Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization.Veterinary research communications · 2025Article
- Histological and immunohistochemical characterization of granulomas in alpacas (Frontiers in veterinary science · 2025Article
- Genetic diversity and antibiotic resistance ofFrontiers in cellular and infection microbiology · 2025Article
- An Overview of a Re-Emerging Disease in Italy: Bovine Tuberculosis Outbreaks in Cattle from MTBC-Free Territories.Pathogens (Basel, Switzerland) · 2024Article
- Case report: Discovery of tuberculosis caused byFrontiers in veterinary science · 2024Article
- Will we ever eradicate animal tuberculosis?Irish veterinary journal · 2023Article
- Prevalence and Molecular Characterization ofMicroorganisms · 2022Article
- Real-time PCR using atpE, conventional PCR targeting different regions of difference, and flow cytometry for confirmation of Mycobacterium bovis in buffaloes and cattle from the Delta area of Egypt.BMC microbiology · 2022Article
- Detection of Mycobacterium tuberculosis complex DNA in oronasal swabs from infected African buffaloes (Syncerus caffer).Scientific reports · 2022Article
- High prevalence of extrapulmonary tuberculosis in dairy farms: Evidence for possible gastrointestinal transmission.PloS one · 2021Article
- Prevalence of Bovine Tuberculosis in Slaughtered Cattle in Sicily, Southern Italy.Animals : an open access journal from MDPI · 2020Article
- Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis.Veterinary research · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Animal tuberculosis (TB) remains a major problem in some countries despite the existence of control programmes focused mainly on cattle. In this species, aerogenous transmission is accepted as the most frequent infection route, affecting mainly the respiratory system. Under the hypothesis that the oral route could be playing a more relevant role in transmission, diagnosis and disease persistence than previously thought, this study was performed to assess the course of TB infection in cattle and its effects on diagnosis depending on the route of entry of Mycobacterium bovis. Two groups of five calves each were either endotracheally (EC) or orally (OC) challenged. Necropsies were carried out 12 weeks after challenge except for three OC calves slaughtered 8 weeks later. All animals reacted to the tuberculin skin test and the entire EC group was positive to the interferon-gamma release assay (IGRA) 2 weeks after challenge and thereafter. The first positive IGRA results for OC calves (3/5) were recorded 4 weeks after challenge. Group comparison revealed significant differences in lesion and positive culture location and scoring. TB-compatible gross lesions and positive cultures were more frequently found in the thorax (p < 0.001) and lung (p < 0.05) of EC animals, whereas OC animals presented lesions (p = 0.23) and positive cultures (p < 0.05) mainly located in the abdomen. These results indicate that the infection route seems to be a determining factor for both the distribution and the time needed for the development of visible lesions. Our study suggests that confirmation of TB infection in some skin reactor animals can be problematic if current post-mortem examination and diagnostics are not improved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.