ArticleRespiratory research2018
Decreased microbiome diversity in the HIV small airway epithelium.
Article in Respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Human Immunodeficiency Virus on Lung Function and Structure: A Systematic Review and Meta-Analysis.Annals of the American Thoracic Society · 2025Pooled it
- The Effects of Corticosteroids on the Respiratory Microbiome: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Analysis of pharyngeal microbiome characteristics in HIV-infected individuals: correlation between the degree of immunosuppression and microbial dysbiosis.BMC infectious diseases · 2026Article
- Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi'omics profiling.Respiratory research · 2023Article
- Article
- Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Article
- Blue Light Alters the Composition of the Jejunal Microbiota and Promotes the Development of the Small Intestine by Reducing Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Article
- Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Pediatric lung transplantation: Dynamics of the microbiome and bronchiolitis obliterans in cystic fibrosis.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2020Observational
- Enrichment of the airway microbiome in people living with HIV with potential pathogenic bacteria despite antiretroviral therapy.EClinicalMedicine · 2020Article
- Methods in Lung Microbiome Research.American journal of respiratory cell and molecular biology · 2020Review
- Pathogenesis and management of emphysema in people with HIV.Expert review of respiratory medicineReview
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundPersons living with human immunodeficiency virus (PLWH) face an increased burden of chronic obstructive pulmonary disease (COPD). Repeated pulmonary infections, antibiotic exposures, and immunosuppression may contribute to an altered small airway epithelium (SAE) microbiome.
methodsSAE cells were collected from 28 PLWH and 48 HIV- controls through bronchoscopic cytologic brushings. DNA extracted from SAE cells was subjected to 16S rRNA amplification and sequencing. Comparisons of alpha and beta diversity between HIV+ and HIV- groups were performed and key operational taxonomic units (OTUs) distinguishing the two groups were identified using the Boruta feature selection after Random Forest Analysis.
resultsPLWH demonstrated significantly reduced Shannon diversity compared with HIV- volunteers (1.82 ± 0.10 vs. 2.20 ± 0.073, p = 0.0024). This was primarily driven by a reduction in bacterial richness (23.29 ± 2.75 for PLWH and 46.04 ± 3.716 for HIV-, p < 0.0001). Phyla distribution was significantly altered among PLWH, with an increase in relative abundance of Proteobacteria (p = 0.0003) and a decrease in Bacteroidetes (p = 0.0068) and Firmicutes (p = 0.0002). Six discriminative OTUs were found to distinguish PLWH from HIV- volunteers, aligning to Veillonellaceae, Fusobacterium, Verrucomicrobiaceae, Prevotella, Veillonella, and Campylobacter.
conclusionsCompared to HIV- controls, PLWH's SAE microbiome is marked by reduced bacterial diversity and richness with significant differences in community composition.
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