ArticleMicrobial cell factories2018
Engineered global regulator H-NS improves the acid tolerance of E. coli.
Article in Microbial cell factories, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Toehold Switch-Based Approach for Engineering Acid-Tolerance Modules to Enhance Production Robustness of Industrial E. coli Strains at Low pH.Microbial biotechnology · 2025Article
- Advances in stress-tolerance elements for microbial cell factories.Synthetic and systems biotechnology · 2024Review
- Disentangling the Regulatory Response ofACS synthetic biology · 2024Article
- Engineering quorum sensing-based genetic circuits enhances growth and productivity robustness of industrial E. coli at low pH.Microbial cell factories · 2024Article
- Characterization of Mild Acid Stress Response in an Engineered Acid-TolerantMicroorganisms · 2024Article
- Advance of tolerance engineering on microbes for industrial production.Synthetic and systems biotechnology · 2023Review
- Synthesis of isobutanol using acetate as sole carbon source in Escherichia coli.Microbial cell factories · 2023Article
- Enhancement of acid tolerance of Escherichia coli by introduction of molecule chaperone CbpA from extremophile.World journal of microbiology & biotechnology · 2023Article
- Identification of a major facilitator superfamily protein that is beneficial to L-lactic acid production by Bacillus coagulans at low pH.BMC microbiology · 2022Article
- Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced Bacillus subtilis strain and improves its metabolite production.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Achieving "Non-Foaming" Rhamnolipid Production and Productivity Rebounds ofMicroorganisms · 2022Article
- Mediator Engineering ofApplied and environmental microbiology · 2022Article
- Synthetic acid stress-tolerance modules improve growth robustness and lysine productivity of industrial Escherichia coli in fermentation at low pH.Microbial cell factories · 2022Article
- Enhancing biofuels production by engineering the actin cytoskeleton in Saccharomyces cerevisiae.Nature communications · 2022Article
- TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription.Nature chemical biology · 2022Article
- Engineering of the Small Noncoding RNA (sRNA) DsrA Together with the sRNA Chaperone Hfq Enhances the Acid Tolerance of Escherichia coli.Applied and environmental microbiology · 2021Article
- Foaming of rhamnolipids fermentation: impact factors and fermentation strategies.Microbial cell factories · 2021Review
- Histone-Like Nucleoid Structuring Protein Modulates the Fitness ofFrontiers in microbiology · 2021Article
- Engineering Lactococcus lactis as a multi-stress tolerant biosynthetic chassis by deleting the prophage-related fragment.Microbial cell factories · 2020Article
- SdiA Improves the Acid Tolerance ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAcid stress is often encountered during industrial fermentation as a result of the accumulation of acidic metabolites. Acid stress increases the intracellular acidity and can cause DNA damage and denaturation of essential enzymes, thus leading to a decrease of growth and fermentation yields. Although acid stress can be relieved by addition of a base to the medium, fermentations with acid-tolerant strains are generally considered much more efficient and cost-effective.
resultsIn this study, the global regulator H-NS was found to have significant influence on the acid tolerance of E. coli. The final OD
conclusionsThe results obtained in this work demonstrate that the engineering of H-NS can enhance the acid tolerance of E. coli. More in general, this study shows the potential of the engineering of global regulators acting as repressors, such as H-NS, as a promising method to obtain phenotypes of interest. This approach could expand the spectrum of application of global transcription machinery engineering.
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