ArticleBMC musculoskeletal disorders2018
Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A systematic review of the association between ultrasound-detected features and laboratory inflammatory biomarkers in hand osteoarthritis.Annals of medicine · 2025Pooled it
- Clusterin serum levels are elevated in patients with early rheumatoid arthritis and predict disease activity and treatment response.Scientific reports · 2021Trial
- Protocol for a Prospective Cohort Study on Determinants of Outcomes in Lumbar Radiculopathy Surgery.Healthcare (Basel, Switzerland) · 2025Article
- Protective effect of clusterin against interleukin-1β-induced apoptosis and inflammation in human knee osteoarthritis chondrocytes.Clinical and translational science · 2024Article
- Positive and Negative Effects of Administering a Magnetic Field to Patients with Rheumatoid Arthritis (RA).Journal of clinical medicine · 2024Article
- The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis.Frontiers in immunology · 2023Article
- Clusterin exacerbates interleukin-1β-induced inflammation via suppressing PI3K/Akt pathway in human fibroblast-like synoviocytes of knee osteoarthritis.Scientific reports · 2022Article
- Deregulated Clusterin as a Marker of Bone Fragility: New Insights into the Pathophysiology of Osteoporosis.Genes · 2022Article
- Erosive hand osteoarthritis: latest findings and outlook.Nature reviews. Rheumatology · 2022 · on this mapReview
- The repair effect and mechanism of continuous passive motion on osteoarthritis in a rabbit model.American journal of translational research · 2022Article
- Exploring the translational potential of clusterin as a biomarker of early osteoarthritis.Journal of orthopaedic translation · 2022Review
- Clusterin Is Associated with Systemic and Synovial Inflammation in Knee Osteoarthritis.Cartilage · 2021Article
- An implementation study of periarticular knee osteotomy in the treatment of knee osteoarthritis.American journal of translational research · 2021Article
- Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis.Biomolecules · 2020Article
- Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia.Scientific reports · 2020Article
- Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected withPathogens (Basel, Switzerland) · 2020Article
- Clusterin silencing restores myoblasts viability and down modulates the inflammatory process in osteoporotic disease.Journal of translational medicine · 2019Article
- Plasma Protein Pattern Correlates With Pain Intensity and Psychological Distress in Women With Chronic Widespread Pain.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters.
methodsA total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA).
resultsSerum levels of CLU were significantly lower in patients with hand OA than in control subjects (p < 0.0001). In addition, patients with erosive hand OA had significantly lower CLU levels than those with non-erosive disease (p = 0.044). Negative correlations between CLU levels and pain as assessed by the AUSCAN score and the VAS were found in patients with erosive hand OA (r = - 0.275; p = 0.013 and r = - 0.220; p = 0.049, respectively).
conclusionThe present study demonstrates that lower concentrations of CLU are found in hand OA patients than in healthy individuals, especially in those with erosive disease, and that CLU concentrations have a negative association with hand pain.
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