Evidence map›Paper›PMID 30053805›Full record

SynthesisBMC medical genetics2018

Cumulative evidence for relationships between multiple variants of HNF1B and the risk of prostate and endometrial cancers.

Yu Tong, Yi Qu, Shiping Li, Fengyan Zhao, Yibin Wang, Dezhi Mu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu TongDepartment of Pediatrics, West China Second University Hospital, Sichuan University, No.17, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan Province, China.ORCID 0000-0002-1744-6020
Yi QuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, No.17, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan Province, China.
Shiping LiDepartment of Pediatrics, West China Second University Hospital, Sichuan University, No.17, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan Province, China.
Fengyan ZhaoDepartment of Pediatrics, West China Second University Hospital, Sichuan University, No.17, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan Province, China.
Yibin WangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, No.17, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan Province, China. yibinwang666@163.com.
Dezhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, No.17, Section 3, Renmin Nan Road, Chengdu, 610041, Sichuan Province, China. mudz@scu.edu.cn.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo provide a synopsis of the current understanding of the association between variants of HNF1B and cancer susceptibility, we conducted a comprehensive research synopsis and meta-analysis to evaluate associations between HNF1B variants and prostate and endometrial cancers.

resultsEighteen studies totaling 34,937 patients and 55,969 controls were eligible for this meta-analysis. Four variants showed a significant association with the risk of individual cancer. Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10

conclusionsOur study summarizes the evidence and helps to reveal that common variants of HNF1B are associated with risk of prostate and endometrial cancer.

Indexed as

Case-Control StudiesEndometrial NeoplasmsFemaleGenetic Predisposition to DiseaseGenotypeHepatocyte Nuclear Factor 1-betaHumansMalePolymorphism, Single NucleotideProstateProstatic NeoplasmsRisk FactorsHepatocyte Nuclear Factor 1-betaHNF1B protein, humanEndometrial cancerHNF1BProstate cancerVariants

Identifiers

PMID30053805
PMCPMC6062884
OpenAlexW2883919093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.