ReviewCurrent opinion in virology2018
The parts are greater than the whole: the role of semi-infectious particles in influenza A virus biology.
Review in Current opinion in virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Secondary analysis of influenza a virus-infected cells at single-cell resolution reveals host BANF1 response to individual and combinations of detected segments.Virology journal · 2026Article
- Host PI3K inhibition via anti-cancer drug alpelisib influences Influenza A non-infectious particles and deletion-containing viral genomes.Cell communication and signaling : CCS · 2025Article
- Living Together Apart: Quantitative Perspectives on the Costs and Benefits of a Multipartite Genome Organization in Viruses.Viruses · 2025Article
- Aspects of the lifestyle of multipartite viruses apply to monopartite segmented and perhaps nonsegmented viruses.Npj viruses · 2024Review
- Robust Approaches to the Quantitative Analysis of Genome Formula Variation in Multipartite and Segmented Viruses.Viruses · 2024Article
- The genome formula of a multipartite virus is regulated both at the individual segment and the segment group levels.PLoS pathogens · 2024Article
- The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy.Scientific reports · 2023Article
- Evaluation of sequencing and PCR-based methods for the quantification of the viral genome formula.Virus research · 2023Article
- Article
- Incomplete bunyavirus particles can cooperatively support virus infection and spread.PLoS biology · 2022Article
- A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.Microbiology and molecular biology reviews : MMBR · 2022Review
- Virus-like Particles: Measures and Biological Functions.Viruses · 2022Review
- Gene copy number variations at the within-host population level modulate gene expression in a multipartite virus.Virus evolution · 2022Article
- Selective Genome Packaging Mechanisms of Influenza A Viruses.Cold Spring Harbor perspectives in medicine · 2021Review
- Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response.PLoS pathogens · 2020Article
- Single cell heterogeneity in influenza A virus gene expression shapes the innate antiviral response to infection.PLoS pathogens · 2020Article
- A method for the unbiased quantification of reassortment in segmented viruses.Journal of virological methods · 2020Article
- Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation.PLoS pathogens · 2020Article
- Influenza viruses that require 10 genomic segments as antiviral therapeutics.PLoS pathogens · 2019Article
- Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The influenza A virus (IAV) genome is incorporated into newly produced virions through a tightly orchestrated process that is one of the best studied examples of genome packaging by a segmented virus. Despite the remarkable selectivity and efficiency of this process, it is clear that the vast majority of IAV virions are unable to express the full set of essential viral gene products and are thus incapable of productive replication in the absence of complementation. Here, we attempt to reconcile the widespread production of these semi-infectious particles (SIPs) with the high efficiency and selectivity of IAV genome packaging. We also cover what is known and what remains unknown about the consequences of SIP production for the replication and evolution of viral populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.