Evidence map›Paper›PMID 30053608›Full record

ArticleBone2018

Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes.

Christopher Dedic, Tin Shing Hung, Alan M Shipley, Akira Maeda, Thomas Gardella, Andrew L Miller, Paola Divieti Pajevic, Joseph G Kunkel, Alessandro Rubinacci

Abstract read
In one paragraph

Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Systemic Bone Loss After Fracture.Clinical reviews in bone and mineral metabolism · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Christopher DedicMolecular and Cell Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Tin Shing HungDivision of Life Sciences, State Key Laboratory for Molecular Neuroscience, HKUST, Hong Kong, China.
Alan M ShipleyApplicable Electronics, LLC, New Haven, CT, USA.
Akira MaedaEndocrine Unit, Massachusetts General Hospital, Boston, USA; Chugai Pharmaceutical, Japan.
Thomas GardellaEndocrine Unit, Massachusetts General Hospital, Boston, USA.
Andrew L MillerDivision of Life Sciences, State Key Laboratory for Molecular Neuroscience, HKUST, Hong Kong, China.
Paola Divieti PajevicMolecular and Cell Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Joseph G KunkelPickus Center for Biomedical Research, University of New England, Biddeford, ME, USA.
Alessandro RubinacciBone Metabolism Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy. Electronic address: alessandro.rubinacci@hsr.it.
Boston University · USHong Kong University of Science and Technology · HKMassachusetts General Hospital · USUniversity of New England · USVita-Salute San Raffaele University · IT

Funding

Tissue Phenotyping CoreP01DK011794 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BOUXSEIN, MARY L · 1986 to 2023
$44.4M
Skeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5M
Actions of Parathyroid Hormone (PTH)/PTH related-peptide receptor in Osteocytes iR01DK079161 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DIVIETI PAJEVIC, PAOLA · 2009 to 2013
$1.9M
Actions of Parathyroid Hormone(PTH)/PTH related-peptide receptor in Osteocytes inR56DK079161 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DIVIETI PAJEVIC, PAOLA · 2008 to 2008
$116k
NIAMS NIH HHS P30 AR066261NIDDK NIH HHS P01 DK011794NIDDK NIH HHS R01 DK079161NIDDK NIH HHS R56 DK079161
6 · The paper itself

Abstract

Calcium ion concentration ([Ca

Indexed as

Gene DeletionAnimalsBone and BonesBone DensityCalciumColforsinCyclic AMPFibroblast Growth Factor-23HumansMaleMetatarsal BonesMice, Inbred C57BLOsteocytesParathyroid HormonePlasmaReceptor, Parathyroid Hormone, Type 1CalciumColforsinCyclic AMPFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Parathyroid HormoneReceptor, Parathyroid Hormone, Type 1Calcium homeostasisOsteocytesPTHScanning ion-selective electrode technique (SIET)

Identifiers

PMID30053608
PMCPMC6158063
OpenAlexW2884993033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.