Evidence map›Paper›PMID 30053441›Full record

ReviewAdvanced drug delivery reviews2018

3D bioprinting for cardiovascular regeneration and pharmacology.

Haitao Cui, Shida Miao, Timothy Esworthy, Xuan Zhou, Se-Jun Lee, Chengyu Liu, Zu-Xi Yu, John P Fisher, Muhammad Mohiuddin, Lijie Grace Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Human cardiovascular organoids: Biomedical applications and ethical challenges.American heart journal plus : cardiology research and practice · 2026
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haitao CuiDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Shida MiaoDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Timothy EsworthyDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Xuan ZhouDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Se-Jun LeeDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Chengyu LiuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zu-Xi YuNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
John P FisherFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA; Center for Engineering Complex Tissues, University of Maryland, College Park, MD 20742, USA.
Muhammad MohiuddinDepartment of Surgery, University of Maryland, Baltimore, MD 21201, USA.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA; Department of Medicine, The George Washington University, Washington, DC 20052, USA. Electronic address: lgzhang@gwu.edu.

Funding

Pathology CoreZICHL005904 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YU, ZU XI · 2010 to 2023
$11.6M
A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of the most advanced techniques for creating complicated cardiovascular implants with biomimetic features, which are capable of recapitulating both the native physiochemical and biomechanical characteristics of the cardiovascular system. The present review provides an overview of the cardiovascular system, as well as describes the principles of, and recent advances in, 3D bioprinting cardiovascular tissues and models. Moreover, this review will focus on the applications of 3D bioprinting technology in cardiovascular repair/regeneration and pharmacological modeling, further discussing current challenges and perspectives.

Indexed as

BioprintingPrinting, Three-DimensionalRegenerationBiomimetic MaterialsCardiovascular SystemHumansTissue Engineering3D bioprintingCardiac tissueCardiovascularMyocardiumPharmacologyRegenerationTissue modelValvesVasculature

Identifiers

PMID30053441
PMCPMC6226324

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.