Evidence map›Paper›PMID 30053414›Full record

ArticleBio Systems2018

Tellurium: An extensible python-based modeling environment for systems and synthetic biology.

Kiri Choi, J Kyle Medley, Matthias König, Kaylene Stocking, Lucian Smith, Stanley Gu, Herbert M Sauro

Abstract read
In one paragraph

Article in Bio Systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kiri ChoiDepartment of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Seattle, WA 98195, USA. Electronic address: kirichoi@uw.edu.
J Kyle MedleyDepartment of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Seattle, WA 98195, USA. Electronic address: medjk@comcast.net.
Matthias KönigInstitute for Biology, Institute for Theoretical Biology, Humboldt University, Berlin, Germany. Electronic address: koenigmx@hu-berlin.de.
Kaylene StockingDepartment of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Seattle, WA 98195, USA. Electronic address: viola.sox@gmail.com.
Lucian SmithDepartment of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Seattle, WA 98195, USA. Electronic address: lucianoelsmitho@gmail.com.
Stanley GuDepartment of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Seattle, WA 98195, USA. Electronic address: stanleygu@gmail.com.
Herbert M SauroDepartment of Bioengineering, University of Washington, William H. Foege Building, Box 355061, Seattle, WA 98195, USA. Electronic address: hsauro@u.washington.edu.

Funding

Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demandU01HL122199 · NHLBI · UNIVERSITY OF WASHINGTON · PI BEARD, DANIEL A, DASH, RANJAN K · 2015 to 2019
$3.3M
Continued Development and Maintenance of the Systems Biology WorkbenchR01GM081070 · NIGMS · UNIVERSITY OF WASHINGTON · PI SAURO, HERBERT M. · 2007 to 2014
$1.7M
High Performance Simulation Libraries for Systems BiologyR01GM123032 · NIGMS · UNIVERSITY OF WASHINGTON · PI SAURO, HERBERT M. · 2017 to 2020
$1.7M
NHLBI NIH HHS U01 HL122199NIGMS NIH HHS R01 GM081070NIGMS NIH HHS R01 GM123032
6 · The paper itself

Abstract

Here we present Tellurium, a Python-based environment for model building, simulation, and analysis that facilitates reproducibility of models in systems and synthetic biology. Tellurium is a modular, cross-platform, and open-source simulation environment composed of multiple libraries, plugins, and specialized modules and methods. Tellurium is a self-contained modeling platform which comes with a fully configured Python distribution. Two interfaces are provided, one based on the Spyder IDE which has an accessible user interface akin to MATLAB and a second based on the Jupyter Notebook, which is a format that contains live code, equations, visualizations, and narrative text. Tellurium uses libRoadRunner as the default SBML simulation engine which supports deterministic simulations, stochastic simulations, and steady-state analyses. Tellurium also includes Antimony, a human-readable model definition language which can be converted to and from SBML. Other standard Python scientific libraries such as NumPy, SciPy, and matplotlib are included by default. Additionally, we include several user-friendly plugins and advanced modules for a wide-variety of applications, ranging from complex algorithms for bifurcation analysis to multidimensional parameter scanning. By combining multiple libraries, plugins, and modules into a single package, Tellurium provides a unified but extensible solution for biological modeling and analysis for both novices and experts. AVAILABILITY: tellurium.analogmachine.org.

Indexed as

Models, BiologicalSynthetic BiologySystems BiologyReproducibility of ResultsTelluriumTelluriumSBMLSimulationSoftwareSystems biology

Identifiers

PMID30053414
PMCPMC6108935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.