Evidence map›Paper›PMID 30053214›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2019

Regional variation in the treatment and prevention of peritoneal dialysis-related infections in the Peritoneal Dialysis Outcomes and Practice Patterns Study.

Neil Boudville, David W Johnson, Junhui Zhao, Brian A Bieber, Ronald L Pisoni, Beth Piraino, Judith Bernardini, Sharon J Nessim, Yasuhiko Ito, Graham Woodrow and 5 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 8 countries.

Neil BoudvilleMedical School, University of Western Australia, Perth, Western Australia, Australia.
David W JohnsonDepartment of Nephrology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Junhui ZhaoArbor Research Collaborative for Health, Ann Arbor, MI, USA.
Brian A BieberArbor Research Collaborative for Health, Ann Arbor, MI, USA.
Ronald L PisoniArbor Research Collaborative for Health, Ann Arbor, MI, USA.
Beth PirainoDepartment of Medicine, Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, USA.
Judith BernardiniDepartment of Medicine, Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, USA.
Sharon J NessimDepartment of Nephrology, Division of Nephrology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Yasuhiko ItoDepartment of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Nagakute, Japan.
Graham WoodrowDepartment of Nephrology, St James's University Hospital, Leeds, UK.
Fiona BrownDepartment of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
John CollinsDepartment of Renal Medicine, Auckland City Hospital, Auckland, New Zealand.
Talerngsak KanjanabuchDivision of Nephrology, Department of Internal Medicine, and Kidney & Metabolic Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Cheuk-Chun SzetoCarol & Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China.
Jeffrey PerlDepartment of Medicine, Division of Nephrology, St. Michael's Hospital and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Arbor Research Collaborative for Health · USUniversity of Pittsburgh · USAichi Medical University · JPAuckland City Hospital · NZChinese University of Hong Kong · HKChulalongkorn University · THJewish General Hospital · CAMonash Medical Centre · AUPrincess Alexandra Hospital · AUSt James's University Hospital · GBSt. Michael's Hospital · CAThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeritoneal dialysis (PD)-related infections lead to significant morbidity. The International Society for Peritoneal Dialysis (ISPD) guidelines for the prevention and treatment of PD-related infections are based on variable evidence. We describe practice patterns across facilities participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).

methodsPDOPPS, a prospective cohort study, enrolled nationally representative samples of PD patients in Australia/New Zealand (ANZ), Canada, Thailand, Japan, the UK and the USA. Data on PD-related infection prevention and treatment practices across facilities were obtained from a survey of medical directors'.

resultsA total of 170 centers, caring for >11 000 patients, were included. The proportion of facilities reporting antibiotic administration at the time of PD catheter insertion was lowest in the USA (63%) and highest in Canada and the UK (100%). Exit-site antimicrobial prophylaxis was variably used across countries, with Japan (4%) and Thailand (28%) having the lowest proportions. Exit-site mupirocin was the predominant exit-site prophylactic strategy in ANZ (56%), Canada (50%) and the UK (47%), while exit-site aminoglycosides were more common in the USA (72%). Empiric Gram-positive peritonitis treatment with vancomycin was most common in the UK (88%) and USA (83%) compared with 10-45% elsewhere. Empiric Gram-negative peritonitis treatment with aminoglycoside therapy was highest in ANZ (72%) and the UK (77%) compared with 10-45% elsewhere.

conclusionsVariation in PD-related infection prevention and treatment strategies exist across countries with limited uptake of ISPD guideline recommendations. Further work will aim to understand the impact these differences have on the wide variation in infection risk between facilities and other clinically relevant PD outcomes.

Indexed as

AgedAnti-Bacterial AgentsAntibiotic ProphylaxisBacteriaBacterial InfectionsCatheters, IndwellingFemaleHumansInternational AgenciesMaleMiddle AgedPeritoneal DialysisPeritonitisPractice Patterns, Physicians'PrognosisProspective StudiesAnti-Bacterial Agentsinfectionperitoneal dialysisperitonitis

Identifiers

PMID30053214
PMCPMC6887924
OpenAlexW2883904868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.