Evidence map›Paper›PMID 30053207›Full record

ArticleJournal of the National Cancer Institute2017

Multigene Expression Assay and Benefit of Radiotherapy After Breast Conservation in Ductal Carcinoma in Situ.

Eileen Rakovitch, Sharon Nofech-Mozes, Wedad Hanna, Rinku Sutradhar, Frederick L Baehner, Dave P Miller, Cindy Fong, Sumei Gu, Alan Tuck, Sandip Sengupta and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  18. Breast cancer gene expression signatures: development and clinical significance-a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 2 countries.

Eileen RakovitchAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Sharon Nofech-MozesAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Wedad HannaAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Rinku SutradharAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Frederick L BaehnerAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Dave P MillerAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Cindy FongAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Sumei GuAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Alan TuckAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Sandip SenguptaAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Leela ElavathilAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Prashant A JaniAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Michel BoninAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Martin C ChangAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Elzbieta SlodkowskaAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Joseph M AndersonAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Diana B CherbavazAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Steven ShakAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Lawrence PaszatAffiliations of authors: Sunnybrook Health Sciences Centre, Toronto, ON, Canada (ER, SNM, WH, ES, LP); Institute for Clinical Evaluative Sciences, Toronto, ON, Canada (ER, RS, SG, LP); University of Toronto, Toronto, ON, Canada (ER, SNM, WH, MCC, LP); Genomic Health, Inc., Redwood City, CA (FLB, DPM, JMA, DBC, SS); University of California, San Francisco (UCSF), San Francisco, CA (FLB); London Health Sciences Centre, London, ON, Canada (AT); Kingston General Hospital, Kingston, ON, Canada (SS); Henderson General Hospital, Hamilton, ON, Canada (LE); Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada (PAJ); Northern Ontario School of Medicine, Thunder Bay, ON, Canada (PAJ); Health Sciences North Sudbury, Sudbury, ON, Canada (MB); Mount Sinai Hospital, Toronto, ON, Canada (MCC).
Thunder Bay Regional Health Sciences Centre · CAGenomic Health (United States) · USHealth Sciences North · CALondon Health Sciences Centre · CANOSM University · CASunnybrook Health Science Centre · CAUniversity of California, San Francisco · USHealth Sciences Centre · CAInstitute for Clinical Evaluative Sciences · CAJuravinski Hospital · CAKingston General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Most women with ductal carcinoma in situ (DCIS) will receive breast-conserving surgery (BCS) and radiation (RT). RT can be omitted for women at low risk of local recurrence (LR). The Oncotype DX DCIS score (DS) predicts LR risk after BCS alone. This study assesses the impact of RT and DS on LR risk. Methods: Population-based cohort analysis of individuals with DCIS treated by BCS ± RT from 1994-2003. Treatment and outcomes were determined by linkage and chart review. We used a propensity score-adjusted multivariable model to examine associations between DS and LR and evaluate the impact of RT. All statistical tests were two-sided. Results: The cohort includes 571 individuals treated by BCS alone, 689 cases treated with BCS + RT. Median follow-up was 9.4 years. On multivariable analysis, factors associated with LR include RT, age at diagnosis, tumor size, and multifocality. Adjusting for these factors, the DS risk group was statistically significantly associated with LR risk (hazard ratio high/intermediate = 1.75, 95% confidence interval = 1.28 to 2.41, P < .001). Women with a low-risk DS treated by BCS alone had an LR risk of 10.6% at 10 years and a small benefit from RT, while those with a high DS had a higher risk of LR (25.4%) after BCS alone and greater benefit from RT. A subgroup of patients with favorable clinicopathological features had a high-risk DS; these patients had a higher than expected risk of LR after BCS alone and a greater benefit with RT. Conclusions: The DS molecular assay improves risk stratification and estimates of RT benefit in individuals with DCIS treated with breast-conserving therapy.

Indexed as

Mastectomy, SegmentalRadiotherapy, ConformalAgedBiomarkers, TumorBreast NeoplasmsCanadaCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCohort StudiesCombined Modality TherapyFemaleFollow-Up StudiesHumansIncidenceMiddle AgedNeoplasm Recurrence, LocalBiomarkers, Tumor

Identifiers

PMID30053207
PMCPMC6233855
OpenAlexW2580285407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.