ArticleMedical mycology2019
Characterizing in vitro spherule morphogenesis of multiple strains of both species of Coccidioides.
Article in Medical mycology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
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- Development and Optimization of Multi-Well Colorimetric Assays for Growth ofJournal of fungi (Basel, Switzerland) · 2025Article
- Coccidioidomycosis: a growing global concern.The Journal of antimicrobial chemotherapy · 2025Review
- From soil to clinic: current advances in understandingMicrobiology and molecular biology reviews : MMBR · 2024Review
- Coccidioides Species: A Review of Basic Research: 2022.Journal of fungi (Basel, Switzerland) · 2022Review
- Characterization of the Growth and Morphology of a BSL-2Journal of fungi (Basel, Switzerland) · 2022Article
- PM10 and Other Climatic Variables Are Important Predictors of Seasonal Variability of Coccidioidomycosis in Arizona.Microbiology spectrum · 2022Article
- A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain "Silveira".G3 (Bethesda, Md.) · 2022Article
- Demonstration ofMicrobiology spectrum · 2021Article
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- A Review ofCurrent clinical microbiology reports · 2021Review
- Differential Thermotolerance Adaptation between Species ofJournal of fungi (Basel, Switzerland) · 2020Article
- Laser Capture Microdissection-Assisted Protein Biomarker Discovery fromJournal of fungi (Basel, Switzerland) · 2020Article
- Proper Care and Feeding of Coccidioides: A Laboratorian's Guide to Cultivating the Dimorphic Stages of C. immitis and C. posadasii.Current protocols in microbiology · 2020Article
- Defining Critical Genes During Spherule Remodeling and Endospore Development in the Fungal Pathogen,Frontiers in genetics · 2020Article
- Early Events in Coccidioidomycosis.Clinical microbiology reviews · 2019Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The disease San Joaquin Valley Fever (coccidioidomycosis) is caused by the inhalation of Coccidioides arthroconidia. In vivo, arthroconidia transform into pathogenic structures termed spherules. Exposure to the host milieu triggers spherule development; however, the molecular mechanisms responsible for the morphological shift are not well characterized. This study compared the morphogenesis of five strains of both species of Coccidioides in two media types to improve the in vitro model of dimorphism that can be easily reproduced, and is amenable to tissue culture. We also sought to establish a modern record of the morphological switch among commonly used lab strains through a detailed account of growth under various conditions. Spherules from five strains were grown in standard (Converse) and experimental media (RPMI-sph). Strain behavior was quantified by median spherule size and spherule concentration, beginning 3 days after inoculation and followed for 10 days of growth. There were significant differences observed among Coccidioides immitis and C. posadasii strains, as well as differences between the in vitro systems.
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Registered trials
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