ArticleJournal of experimental botany2018
GhHUB2, a ubiquitin ligase, is involved in cotton fiber development via the ubiquitin-26S proteasome pathway.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A ubiquitin-GhUBX-GhCDC48 module regulates secondary cell wall thickening in cotton fiber.Plant physiology · 2025Article
- Mitochondrial GPATs protect Arabidopsis from water stress by impacting cuticle and secondary cell wall development.Plant cell reports · 2025Article
- LRM3 positively regulates stem lodging resistance by degradating MYB6 transcriptional repressor in soybean.Plant biotechnology journal · 2025Article
- SlRGLG2-SlBEL2 module regulates drought tolerance in tomato.Plant molecular biology · 2025Article
- Genes Affecting Cotton Fiber Length: A Systematic Review and Meta-Analysis.Plants (Basel, Switzerland) · 2025Article
- Transcriptomic exploration yields novel perspectives on the regulatory network underlying trichome initiation inFrontiers in plant science · 2025Article
- GhATL68b regulates cotton fiber cell development by ubiquitinating the enzyme required for β-oxidation of polyunsaturated fatty acids.Plant communications · 2024Article
- Simultaneous improvement of fiber yield and quality in upland cotton (Molecular breeding : new strategies in plant improvement · 2024Article
- The RING-Type E3 Ubiquitin Ligase GenePlants (Basel, Switzerland) · 2024Article
- The 4Fs of cotton: genome editing of cotton for fiber, food, feed, and fuel to achieve zero hunger.Frontiers in genome editing · 2024Review
- A comprehensive overview of cotton genomics, biotechnology and molecular biological studies.Science China. Life sciences · 2023Review
- Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review.Horticulture research · 2023Article
- Fine mapping and candidate gene analysis of qFL-A12-5: a fiber length-related QTL introgressed from Gossypium barbadense into Gossypium hirsutum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Novel candidate genes for lignin structure identified through genome-wide association study of naturally varyingFrontiers in plant science · 2023Article
- Genomic and GWAS analyses demonstrate phylogenomic relationships of Gossypium barbadense in China and selection for fibre length, lint percentage and Fusarium wilt resistance.Plant biotechnology journal · 2022Article
- Molecular Mechanisms of Plant Trichome Development.Frontiers in plant science · 2022Review
- Multi-Dimensional Molecular Regulation of Trichome Development inFrontiers in plant science · 2022Review
- Genome-Wide Identification and Characterization of GhCOMT Gene Family during Fiber Development and Verticillium Wilt Resistance in Cotton.Plants (Basel, Switzerland) · 2021Article
- Article
- Ubiquitylome analysis reveals the involvement of ubiquitination in the bast fiber growth of ramie.Planta · 2021Article
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9 authors.
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Abstract
Cotton fibers, which are extremely elongated single cells of epidermal seed trichomes and have highly thickened cell walls, constitute the most important natural textile material worldwide. However, the regulation of fiber development is not well understood. Here, we report that GhHUB2, a functional homolog of AtHUB2, controls fiber elongation and secondary cell wall (SCW) deposition. GhHUB2 is ubiquitously expressed, including within fibers. Overexpression of GhHUB2 in cotton increased fiber length and SCW thickness, while RNAi knockdown of GhHUB2 resulted in shortened fibers and thinner cell walls. We found that GhHUB2 interacted with GhKNL1, a transcriptional repressor predominantly expressed in developing fibers, and that GhHUB2 ubiquitinated and degraded GhKNL1 via the ubiquitin-26S proteasome pathway. GhHUB2 negatively regulated GhKNL1 protein levels and lead to the disinhibition of genes such as GhXTH1, Gh1,3-β-G, GhCesA4, GhAGP4, GhCTL1, and GhCOBL4, thus promoting fiber elongation and enhancing SCW biosynthesis. We found that GhREV-08, a transcription factor that participates in SCW deposition and auxin signaling pathway, was a direct target of GhKNL1. In conclusion, our study uncovers a novel function of HUB2 in plants in addition to its monoubiquitination of H2B. Moreover, we provide evidence for control of the fiber development by the ubiquitin-26S proteasome pathway.
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