ArticleBrain : a journal of neurology2018
A functional micro-electrode mapping of ventral thalamus in essential tremor.
Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Essential tremor disrupts rhythmic brain networks during naturalistic movement.Neurobiology of disease · 2025Article
- The role of the motor thalamus in deep brain stimulation for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Structural brain differences in essential tremor and Parkinson's disease deep brain stimulation patients.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Observational
- Using cortico-cerebellar structural patterns to classify early- and late-trained musicians.Human brain mapping · 2023Article
- Review
- Essential tremor amplitude modulation by median nerve stimulation.Scientific reports · 2021Article
- Neurophysiological biomarkers to optimize deep brain stimulation in movement disorders.Neurodegenerative disease management · 2021Review
- Neuroimaging Detectable Differences between Parkinson's Disease Motor Subtypes: A Systematic Review.Movement disorders clinical practice · 2021Review
- Wearable Peripheral Electrical Stimulation Devices for the Reduction of Essential Tremor: A Review.IEEE access : practical innovations, open solutions · 2021Article
- Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor.Science translational medicine · 2020Article
- Probabilistic tractography in the ventrolateral thalamic nucleus: cerebellar and pallidal connections.Brain structure & function · 2020Article
- Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Analyses of biomarkers for tremor using local field potentials recorded from deep brain stimulation electrodes in the thalamus.Brain stimulationArticle
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Deep brain stimulation enables the delivery of therapeutic interventions to otherwise inaccessible areas of the brain while, at the same time, offering the unique opportunity to record from these same regions in awake patients. The posterior ventrolateral thalamus has become a reliable deep brain stimulation target for medically-refractory patients suffering from essential tremor. However, the contribution of the thalamus in essential tremor, and even whether posterior ventrolateral thalamus is the optimal target, remains a matter of ongoing debate. There are several lines of evidence supporting clusters of activity within the posterior ventrolateral thalamus that are important for tremor emergence. In this study we sought to map the functional properties of these clusters through microelectrode recordings during deep brain stimulation surgery. Data were obtained from 10 severely affected patients with essential tremor (12 hemispheres) undergoing deep brain stimulation surgery. Our results demonstrate power and coherence maxima located in the inferior posterior ventrolateral thalamus and immediate ventral region. Moreover, we identified distinct yet overlapping clusters of predominantly efferent (driving) and afferent (feedback) activity, with a preference for more efferent contributors, consistent with a net role in the driving of tremor output. Finally, we demonstrate that resolvable thalamic spiking activity directly relates to background activity and that the strength of tremor may be dictated by phase relationships between efferent and afferent pockets in the posterior ventrolateral thalamus. Taken together, these results provide important evidence for the role of the inferior posterior ventrolateral thalamus and its border region in essential tremor pathophysiology. Such results progress our mechanistic understanding and promote the adoption of next-generation therapies such as high resolution segregated deep brain stimulation electrodes.
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Registered trials
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