ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Do Nationally Representative Cutpoints for Clinical Muscle Weakness Predict Mortality? Results From 9 Years of Follow-up in the Health and Retirement Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Sex-specific handgrip strength thresholds for short-term mortality risk stratification in Mexican older adults: derivation in MHAS and validation in Mex-Cog.European geriatric medicine · 2026Article
- Association Between Bottle-Opening Ability and Muscle Weakness in Patients With Coronary Artery Disease.Circulation reports · 2025Article
- Mental exertion causes impairments in multifinger force deficit during a handgrip strength task in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Physical Strength Is Not Associated With Facial Sexual Dimorphism and Asymmetry in Either Czechs or Cameroonians.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study.Scientific reports · 2024Article
- Article
- Assessment of Force Production in Parkinson's Disease Subtypes.International journal of environmental research and public health · 2021Article
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Heterogeneity of the strength response to progressive resistance exercise training in older adults: Contributions of muscle contractility.Experimental gerontology · 2021Article
- Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline.GeroScience · 2021Article
- Potential Utility of Electrical Impedance Myography in Evaluating Age-Related Skeletal Muscle Function Deficits.Frontiers in physiology · 2021Review
- Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.Aging clinical and experimental research · 2020Article
- Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.Journal of the American Medical Directors Association · 2020Article
- Is perceived neighbourhood physical disorder associated with muscle strength in middle aged and older men and women? Findings from the US health and retirement study.Journal of epidemiology and community health · 2020Article
- What are the association patterns between handgrip strength and adverse health conditions? A topical review.SAGE open medicine · 2020Review
- Cancer-driven changes link T cell frequency to muscle strength in people with cancer: a pilot study.Journal of cachexia, sarcopenia and muscle · 2019Article
- Grip Strength: An Indispensable Biomarker For Older Adults.Clinical interventions in aging · 2019Review
- Physical Function and Survival in Older Adults: A longitudinal study accounting for time-varying effects.Archives of gerontology and geriatricsArticle
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1 author at 1 institution in 1 country.
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Abstract
backgroundMuscle weakness, as measured by handgrip strength, is associated with cardiovascular and all-cause mortality; however, there are wide inconsistencies in the magnitude of these effects due to divergent definitions used to define muscle weakness across studies. Therefore, the objective of this study was to examine the relationship between previously defined sex- and race-specific cutpoints of clinical muscle weakness and early mortality.
methodsData come from the 2006-2014 Health and Retirement Study. Time-varying clinical muscle weakness, as defined by handgrip strength cutpoints, was the primary exposure. Time to death, ascertained from the National Death Index, was the outcome of interest. The association between time-varying clinical muscle weakness and early mortality across a 9-year observation period was determined using Kaplan-Meier methods and extended Cox regression.
resultsOut of the 8,326 individuals in the study, 1,799 deaths (21%) occurred during the observation period. Median follow-up time was 8.3 years (SD ±1.9 years). Weak individuals had a steeper decline in their survival trajectory, compared to non-weak individuals (Log-Rank test, p < .001). After adjusting for sociodemographic factors and time-varying smoking history, weak individuals were over 50% more likely to die earlier than non-weak individuals (hazard ratio [HR] = 1.52, 95% confidence interval [CI] = 1.15, 1.47).
conclusionsThis is the first study to use muscle weakness cutpoints derived in a nationally representative sample to identify those individuals who may be at greatest risk for premature mortality. Results underscore the importance of muscle weakness, as defined by handgrip strength, as a key risk factor for premature mortality in older Americans.
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