ArticleAmerican journal of hypertension2018
Differential Associations of Diastolic and Systolic Pressures With Cerebral Measures in Older Individuals With Mild Cognitive Impairment.
Article in American journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Consistency of associations of systolic and diastolic blood pressure with white matter hyperintensities: A meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2022Pooled it
- Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging.Frontiers in aging neuroscience · 2022Pooled it
- Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Impact of Blood Pressure After Successful Endovascular Therapy for Anterior Acute Ischemic Stroke: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Contrasting associations of diastolic blood pressure with plasma amyloid, tau, and neurodegeneration biomarkers in the Health and Aging Brain Study-Health Disparities (HABS-HD).Journal of Alzheimer's disease : JAD · 2026Article
- Vascular risk factor variability and cognitive impairment in older adults a community-based retrospective study.Scientific reports · 2025Article
- Blood pressure and Alzheimer's disease biomarkers in cognitively unimpaired adults: a multicenter study.The journal of prevention of Alzheimer's disease · 2025Observational
- Blood pressure at age 40 and key features of cerebral small vessel disease at age 70: data from the ACE 1950 Study.BMC cardiovascular disorders · 2025Observational
- Associations of cardiorespiratory fitness with cerebral cortical thickness and gray matter volume across the adult lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- High Blood Pressure Is Associated With Lower Brain Volume and Cortical Thickness in Healthy Young Adults.American journal of hypertension · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- The Relationship of Vascular Aging to Reduced Cognitive Function: Pulsatile and Steady State Arterial Hemodynamics.Pulse (Basel, Switzerland) · 2022Review
- Dose-response association between plasma homocysteine and white matter lesions in patients with hypertension: a case-control study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Plasma aldosterone concentration is associated with white matter lesions in patients with primary aldosteronism.Endocrine · 2022Article
- Contributions of Cerebral Blood Flow to Associations Between Blood Pressure Levels and Cognition: The Age, Gene/Environment Susceptibility-Reykjavik Study.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension.Frontiers in endocrinology · 2021Article
- Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.Stroke · 2020Article
- Associations between cerebral blood flow and structural and functional brain imaging measures in individuals with neuropsychologically defined mild cognitive impairment.Neurobiology of aging · 2020Article
- Diastolic Blood Pressure, Not Just Systolic Blood Pressure, Is Related to Cerebral Measures in Middle Age: Implications for Prospective Studies.American journal of hypertension · 2018Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundReports on the relative importance of the diastolic and systolic blood pressures (DBP and SBP) in age-related cognitive decline are mixed. Investigating the relation between DBP/SBP and functional and structural brain changes could elucidate which of the 2 measures is more critically important for brain function and, consequently, cognitive impairment.
methodsWe investigated the association of SBP and DBP with cortical volume, cerebral blood flow (CBF), and white matter lesions (WML), in nondemented older adults with and without mild cognitive impairment (MCI; N = 265, 185 MCI, mean age = 64 years). Brachial blood pressure was measured twice while seated, and the average of the 2 measures was used. Cortical volume, gray matter (GM) CBF, and WML were estimated using T1-weighted imaging, arterial spin labeling, and fluid attenuation inversion recovery, respectively.
resultsReduced cortical volume was associated with elevated DBP (β= -0.18, P = 0.034) but not with SBP (β = -0.10, P = 0.206). GM CBF was associated with DBP (β = -0.13, P = 0.048) but not with SBP (β = -0.07, P = 0.275). Likewise, CBF within brain regions where MCI patients showed hypoperfusion were only associated with DBP (DBP: β = -0.17, P = 0.005; SBP: β = -0.09, P = 0.120). WML volume was associated with both DBP (β = 0.20, P = 0.005) and SBP (β = 0.30, P < 0.001). For all measures, there was no interaction between DBP/SBP and cognitive status, indicating that these associations were independent of the cognitive status.
conclusionsIndependently of the cognitive status, DBP is more critically important for GM volume and perfusion, whereas WML is associated with both blood pressures, likely reflecting long-term effect of hypertension and autoregulation dysfunction.
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