ArticlePloS one2018
Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 80 citations in OpenAlex.
- Wearable Biosensors for Continuous Monitoring of Chronic Kidney Disease: Materials, Biofluids, and Digital Health Integration.Biosensors · 2026Review
- Enhancing SPR biosensor performance for creatinine detection via plasma polymerized heptylamine coatings.Scientific reports · 2026Article
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- Mathematical modeling of a MoSe₂-based SPR biosensor for detecting SARS-CoV-2 at nM concentrations.Frontiers in bioengineering and biotechnology · 2025Article
- Review
- Nanosensors Based on Bimetallic Plasmonic Layer and Black Phosphorus: Application to Urine Glucose Detection.Sensors (Basel, Switzerland) · 2024Article
- Highly sensitive detection of low-concentration sodium chloride solutions based on a gold-coated prism in Kretschmann setup.Heliyon · 2024Article
- Visible and angular interrogation of Kretschmann-based SPR using hybrid Au-ZnO optical sensor for hyperuricemia detection.Heliyon · 2023Article
- Article
- A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes.Biosensors · 2023Article
- Surface-Enhanced Raman Analysis of Uric Acid and Hypoxanthine Analysis in Fractionated Bodily Fluids.Nanomaterials (Basel, Switzerland) · 2023Article
- SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems.International journal of biomaterials · 2022Review
- Sensitivity Analysis of Single- and Bimetallic Surface Plasmon Resonance Biosensors.Sensors (Basel, Switzerland) · 2021Article
- Design and Numerical Analysis of a Graphene-Coated SPR Biosensor for Rapid Detection of the Novel Coronavirus.Sensors (Basel, Switzerland) · 2021Article
- A metal-organic zeolitic framework with immobilized urease for use in a tapered optical fiber urea biosensor.Mikrochimica acta · 2019Article
- Highly Sensitive and Selective Colorimetric Detection of Creatinine Based on Synergistic Effect of PEG/HgNanomaterials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea and creatinine in solution of various concentrations (non-enzymatic samples). Comparison was made with the presence of urease and creatininase enzymes in the urea and creatinine solutions (enzymatic samples), respectively. Angular interrogation technique was applied using optical wavelengths of 670 nm and 785 nm. The biosensor detects the presence of urea and creatinine at concentrations ranging from 50-800 mM for urea samples and 10-200 mM for creatinine samples. The purpose of studying the enzymatic sample was mainly to enhance the sensitivity of the sensor towards urea and creatinine in the samples. Upon exposure to 670 nm optical wavelength, the sensitivity of 1.4°/M was detected in non-enzymatic urea samples and 4°/M in non-enzymatic creatinine samples. On the other hand, sensor sensitivity as high as 16.2°/M in urea-urease samples and 10°/M in creatinine-creatininase samples was detected. The enhanced sensitivity possibly attributed to the increase in refractive index of analyte sensing layer due to urea-urease and creatinine-creatininase coupling activity. This work has successfully proved the design and demonstrated a proof-of-concept experiment using a low-cost and easy fabrication of Kretschmann based nano-laminated gold film SPR biosensor for detection of urea and creatinine using urease and creatininase enzymes.
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