Evidence map›Paper›PMID 30052476›Full record

ArticleVirulence2018

Anthrax protective antigen is a calcium-dependent serine protease.

Lisanne Storm, Floris J Bikker, Kamran Nazmi, Albert G Hulst, Debora V der Riet-Van Oeveren, Enno C I Veerman, John P Hays, Wendy E Kaman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. The Importance of Therapeutically Targeting the Binary Toxin fromInternational journal of molecular sciences · 2021
    Review
  2. Structure of the cell-binding component of theProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lisanne Storma Department of Medical Microbiology and Infectious Diseases , Erasmus University Medical Centre , Rotterdam , The Netherlands.
Floris J Bikkerb Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam , University of Amsterdam and VU University Amsterdam , Amsterdam , The Netherlands.
Kamran Nazmib Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam , University of Amsterdam and VU University Amsterdam , Amsterdam , The Netherlands.
Albert G Hulstc Department of CBRN Protection , Netherlands Organization for Applied Scientific Research TNO , Rijswijk , The Netherlands.
Debora V der Riet-Van Oeverenc Department of CBRN Protection , Netherlands Organization for Applied Scientific Research TNO , Rijswijk , The Netherlands.
Enno C I Veermanb Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam , University of Amsterdam and VU University Amsterdam , Amsterdam , The Netherlands.
John P Haysa Department of Medical Microbiology and Infectious Diseases , Erasmus University Medical Centre , Rotterdam , The Netherlands.ORCID 0000-0001-9183-4497
Wendy E Kamana Department of Medical Microbiology and Infectious Diseases , Erasmus University Medical Centre , Rotterdam , The Netherlands.
Academic Center for Dentistry Amsterdam · NLErasmus MC · NLNetherlands Organisation for Applied Scientific Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacillus anthracis secretes a three component exotoxin-complex, which contributes to anthrax pathogenesis. Formation of this complex starts with the binding of protective antigen (PA) to its cellular receptor. In this study, we report that PA is a calcium-dependent serine protease and that the protein potentially uses this proteolytic activity for receptor binding. Additionally our findings shed new light on previous research describing the inhibition of anthrax toxins and exotoxin formation. Importantly, inhibition of the proteolytic activity of protective antigen could be a novel therapeutic strategy in fighting B. anthracis-related infections.

Indexed as

Antigens, BacterialBacillus anthracisBacterial ToxinsCalciumHumansProtein BindingSerine Proteasesanthrax toxinAntigens, BacterialBacterial ToxinsCalciumSerine ProteasesANTXR1/2 receptorB. anthraciscalciumProtective antigenserine protease

Identifiers

PMID30052476
PMCPMC6086315
OpenAlexW2883543402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.