ArticleeLife2018
State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- A doubly stochastic renewal framework for partitioning spiking variability.Nature communications · 2025Article
- Latent dynamics of primary sensory cortical population activity structured by fluctuations in the local field potential.Frontiers in computational neuroscience · 2024Article
- Inter and intralaminar excitation of parvalbumin interneurons in mouse barrel cortex.PloS one · 2024Article
- Inter and Intralaminar Excitation of Parvalbumin Interneurons in Mouse Barrel Cortex.bioRxiv : the preprint server for biology · 2023Article
- Norepinephrine links astrocytic activity to regulation of cortical state.Nature neuroscience · 2023Article
- Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing.PloS one · 2023Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Learning the Synaptic and Intrinsic Membrane Dynamics Underlying Working Memory in Spiking Neural Network Models.Neural computation · 2021Article
- The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.The European journal of neuroscience · 2021Review
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Article
- Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Modeling the Short-Term Dynamics ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Mechanisms underlying gain modulation in the cortex.Nature reviews. Neuroscience · 2020Review
- Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices.Frontiers in systems neuroscience · 2020Review
- Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons.Frontiers in synaptic neuroscience · 2020Review
- Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The cellular and synaptic mechanisms driving cell-type-specific function during various cortical network activities and behaviors are poorly understood. Here, we targeted whole-cell recordings to two classes of inhibitory GABAergic neurons in layer 2/3 of the barrel cortex of awake head-restrained mice and correlated spontaneous membrane potential dynamics with cortical state and whisking behavior. Using optogenetic stimulation of single layer 2/3 excitatory neurons we measured unitary excitatory postsynaptic potentials (uEPSPs) across states. During active states, characterized by whisking and reduced low-frequency activity in the local field potential, parvalbumin-expressing neurons depolarized and, albeit in a small number of recordings, received uEPSPs with increased amplitude. In contrast, somatostatin-expressing neurons hyperpolarized and reduced firing rates during active states without consistent change in uEPSP amplitude. These results further our understanding of neocortical inhibitory neuron function in awake mice and are consistent with the hypothesis that distinct genetically-defined cell classes have different state-dependent patterns of activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.