Evidence map›Paper›PMID 30051912›Full record

ArticleEuropean journal of immunology2018

IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms.

Sílvia Pires, Dane Parker

Abstract read
In one paragraph

Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Interferon Lambda: The Next Frontier in Antiviral Therapy?Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2023
    Review
  14. Review
  15. Clinical Impact ofAntibiotics (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sílvia PiresDepartment of Pediatrics, Columbia University, New York, NY, USA.
Dane ParkerDepartment of Pediatrics, Columbia University, New York, NY, USA.ORCID 0000-0001-7304-3392
Rutgers, The State University of New Jersey · US

Funding

ROLE OF TYPE III INTERFERONS IN STAPHYLOCOCCUS AUREUS RESPIRATORY TRACT INFECTIONR01HL134870 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PARKER, DANE · 2017 to 2020
$1.8M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
Role of interferons in Staphylococcus aureus upper respiratory tract infectionR56HL125653 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARKER, DANE · 2015 to 2015
$384k
NCRR NIH HHS S10 RR027050NHLBI NIH HHS R01 HL134870NHLBI NIH HHS R56 HL125653NIH HHS R01HL134870NIH HHS R56HL125653NIH HHS S10RR027050
6 · The paper itself

Abstract

Maintaining balanced levels of IL-1β is extremely important to avoid host tissue damage during infection. Our goal was to understand the mechanisms behind the reduced pathology and decreased bacterial burdens in Ifnlr1

Indexed as

AnimalsCaspase 1Immunity, InnateInflammasomesInterleukin-1betaLeukocyte ElastaseLungMiceMice, Inbred C57BLMice, KnockoutNeutrophilsNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, InterferonStaphylococcal InfectionsStaphylococcus aureusCaspase 1IFNLR1 protein, mouseInflammasomesInterleukin-1betaLeukocyte ElastaseNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, InterferonIL-1β activationInflammasomeLung infectionStaphylococcus aureusType III interferon

Identifiers

PMID30051912
PMCPMC6394835
OpenAlexW2883136071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.